PEG-Mal-PEG is a chemical compound that belongs to the class of polyethylene glycol (PEG) derivatives. This compound contains two functional groups: a maleimide group (-Mal) and two PEG chains. The maleimide group is known for its ability to react selectively with thiol groups (-SH) on other molecules, forming a stable thioether linkage.
PEG-Mal-PEG has been extensively utilized in the development of novel drug delivery systems. Its unique chemical properties allow for the covalent attachment of therapeutic agents, such as proteins and peptides, to the PEG chain via thioether bonds. The resulting conjugates exhibit improved stability, increased solubility, and prolonged circulation time in vivo, leading to enhanced therapeutic efficacy and reduced side effects.
In addition to its use in drug delivery systems, PEG-Mal-PEG has also been employed as a surface modifier in various biomedical applications.
