Biotin-PEG-NHS Ester

Biotin-PEG-NHS ester is a versatile molecule commonly used in drug research and development. It belongs to the class of PEGylated molecules, which are widely used in pharmaceuticals due to their ability to enhance drug solubility, bioavailability, and circulation time in the body. Biotin-PEG-NHS ester is characterized by the presence of three distinct functional groups, including a biotin moiety, a PEG linker, and an NHS ester. These functional groups confer unique properties to the molecule, making it suitable for various applications in drug research and development.

The biotin moiety of Biotin-PEG-NHS ester is a vitamin that is essential for various biological processes. It binds with high affinity to the protein avidin, making it useful for labeling and detection of proteins. The PEG linker in Biotin-PEG-NHS ester serves as a spacer between the biotin moiety and the NHS ester, allowing for the attachment of the molecule to various biomolecules. Finally, the NHS ester functional group of Biotin-PEG-NHS ester enables covalent attachment of the molecule to amino groups of proteins and peptides.

Given its unique combination of functional groups, Biotin-PEG-NHS ester has become a valuable tool in drug research and development. It is commonly used for site-specific modification of proteins, drug delivery, and targeted imaging. Furthermore, it has been used to improve the pharmacokinetic properties of various drugs, including peptides, proteins, and small molecules.