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β-Glucuronide Linkers is an enzyme-labile linker used in the development of antibody-drug conjugates. The β-Glucuronide and cytotoxic drug conjugate complex undergoes cleavage by β-glucuronidase and releases the cytotoxic drug. β-glucuronidase is an enzyme present in lysosomes and over expressed in some tumors.

Unlike dipeptide-based ADCs that is prone to aggregation. The hydrophilic properties of β-glucuronide linkers may potentially reduce aggregation of the hydrophobic drugs and promote the solubility of the intact antibody-drug conjugates.

Catalog# Name Structure M.W. Purity Pricing
β-Glucuronide Linkers
AP10901β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine
Quick viewβ-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine
748.74≥95% Pricing
AP10975β-tetraacetylglucopyranoside-glycerol
Quick viewβ-tetraacetylglucopyranoside-glycerol
422.38≥95% Pricing
AP10974β-tetraacetylglucopyranoside-glycol
Quick viewβ-tetraacetylglucopyranoside-glycol
392.36≥95% Pricing
AP10153(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
Quick view(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate
913.84≥95% Pricing
AP101524-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate
Quick view4-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate
483.38≥95% Pricing
AP10154β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate
Quick viewβ-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate
455.42≥95% Pricing

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