β-Glucuronide Linkers is an enzyme-labile linker used in the development of antibody-drug conjugates. The β-Glucuronide and cytotoxic drug conjugate complex undergoes cleavage by β-glucuronidase and releases the cytotoxic drug. β-glucuronidase is an enzyme present in lysosomes and over expressed in some tumors.
Unlike dipeptide-based ADCs that are prone to aggregation, β-glucuronide linkers have hydrophilic properties that may potentially reduce aggregation of the hydrophobic drugs and promote the solubility of intact antibody-drug conjugates.
