β-Glucuronide Linkers is an enzyme-labile linker used in the development of antibody-drug conjugates. The β-Glucuronide and cytotoxic drug conjugate complex undergoes cleavage by β-glucuronidase and releases the cytotoxic drug. β-glucuronidase is an enzyme present in lysosomes and over expressed in some tumors.
Unlike dipeptide-based ADCs that is prone to aggregation. The hydrophilic properties of β-glucuronide linkers may potentially reduce aggregation of the hydrophobic drugs and promote the solubility of the intact antibody-drug conjugates.
|AP10901||β-D-triacetylglucopyranosiduronyl methyl ester-phenol-β-Alanine||748.74||≥95%|| Pricing |
|AP10975||β-tetraacetylglucopyranoside-glycerol||422.38||≥95%|| Pricing |
|AP10974||β-tetraacetylglucopyranoside-glycol||392.36||≥95%|| Pricing |
|AP10153||(2S,3S,4S,5R,6S)-methyl-6-(2-(3-((Fmoc-amino)propanamido)-4-PNP-3,4,5-triacetoxy-tetrahydro-2H-pyran-2-carboxylate||913.84||≥95%|| Pricing |
|AP10152||4-Formyl-2-nitrophenyl-β-D-Glucopyranosiduronic Acid Methyl Ester 2,3,4-Triacetate||483.38||≥95%|| Pricing |
|AP10154||β-D-Glucopyranosiduronic acid, 2-amino-4-(hydroxymethyl)phenyl, methyl ester, 2,3,4-triacetate||455.42||≥95%|| Pricing |