PCL Diacid (HOOC‑PCL‑COOH, MW 20K) is linear α,ω‑dicarboxyl‑terminated biodegradable aliphatic polyester. Within the PCL Diacid series ranging from 2K‑20K, this 20 kDa grade possesses maximum hydrophobicity and crystallinity, featuring extremely slow hydrolytic degradation kinetics under physiological conditions. Dual terminal carboxylic acid groups can be activated by EDC/NHS reagents to form amide linkages with amine‑containing peptides, proteins and small‑molecule therapeutics. As a high‑molecular‑weight bifunctional building block, it is suitable for synthesizing high‑strength block copolymers, cross‑linked polymer networks, ultra‑long‑term sustained‑release polymer‑drug conjugates and rigid biodegradable tissue‑engineering scaffolds for biomedical research.
Key Features
- MW: 20000 Da, linear polycaprolactone with carboxyl groups at both chain termini
- The highest hydrophobicity and crystallinity among 2K‑20K PCL Diacid series, ultra‑slow hydrolytic degradation
- Biocompatible high‑crystallinity semi‑crystalline biodegradable polyester
- Dual reactive‑COOH termini; activatable via EDC/NHS for amide coupling with amine‑bearing molecules
- Narrow molecular weight distribution, excellent batch‑to‑batch consistency
- Soluble in DCM, CHCl₃, THF, hot DMF; insoluble in water
Applications
- Synthetic precursor for high‑strength PCL‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins and therapeutic agents upon EDC/NHS activation
- Fabrication of amide‑bonded polymer‑drug conjugates for ultra‑long‑term sustained‑release drug‑delivery research
- Carboxyl‑functional surface modification of high‑rigidity biodegradable tissue‑engineering scaffolds
- Synthetic intermediate for high‑performance degradable polyurethane and polyester polymers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere
- Keep hermetically sealed and dry, avoid moisture‑induced side reactions; prevent repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.