PCL Diacid (HOOC-PCL-COOH), MW 3K is a carboxyl-terminated poly(ε-caprolactone) with carboxylic acid groups at both polymer chain ends. It combines a low-molecular-weight, biodegradable PCL backbone with two terminal carboxyl groups specifically for polymer conjugation, bioconjugation, surface modification, crosslinking, and biomaterial research.
Key Features and Benefits
- Difunctional PCL: Contains terminal carboxyl groups at both ends of the PCL chain, providing two reactive sites for functionalization and conjugation.
- MW 3K: Provides a low molecular weight with good processability specifically for polymer functionalization, formulation, and conjugation research.
- Carboxyl Functionality: The terminal –COOH groups provide reactive sites specifically for coupling with amine-containing molecules through appropriate activation chemistry.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure supports semicrystalline polymer formation and provides useful material-forming properties for biodegradable polymer research.
- Good Processability: The low molecular weight facilitates polymer dissolution, formulation, and chemical modification compared with higher-molecular-weight PCL grades.
- Amide Coupling Platform: The terminal carboxyl groups support activation with EDC/NHS and other suitable coupling reagents for reaction with primary amines.
- Difunctional Conjugation Platform: Two terminal carboxyl groups enable chain extension, crosslinking, end-group modification, and preparation of more complex polymer architectures.
Applications
- Polymer Conjugation: Supports coupling with amine-functionalized polymers and other compatible molecules to prepare block, multiblock, and functional polymer systems.
- EDC/NHS Coupling: Enables activation of terminal carboxyl groups for conjugation with primary amines.
- Amide Bond Formation: Supports formation of stable amide linkages with compatible amine-functionalized molecules and materials.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, and other amine-containing biomolecules.
- Crosslinking: The two terminal carboxyl groups support development of crosslinked or networked polymer systems using suitable multifunctional coupling partners.
- Surface Modification: Enables incorporation of carboxyl-functional PCL into functional surfaces, coatings, and polymeric materials.
- Drug Delivery: Supports development of biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of biodegradable polymers, particles, coatings, composites, networks, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PCL Diacid (HOOC-PCL-COOH), MW 3K provides a low-molecular-weight biodegradable PCL platform with carboxyl groups at both chain ends and good processability and specifically supports amide coupling, chain extension, crosslinking, bioconjugation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.