PDLLA‑Acid (HOOC‑PDLLA‑COOH, MW 2K) is linear α,ω‑dicarboxyl‑terminated amorphous biodegradable polyester. The backbone consists of randomly distributed D‑lactide and L‑lactide repeating units, resulting in fully amorphous structure without crystallinity. This low‑molecular‑weight 2 kDa grade exhibits relatively fast and homogeneous hydrolytic degradation compared with higher‑MW PDLLA‑Acid variants. Dual terminal‑COOH groups can be activated via EDC/NHS carbodiimide chemistry to form amide bonds with amine‑containing peptides, proteins, fluorophores and small‑molecule therapeutics. It serves as a versatile bifunctional building block for block‑copolymer synthesis, bioconjugation, polymer‑drug conjugates and surface functionalization of drug‑delivery nanocarriers for biomedical research.
Key Features
- MW: 2000 Da, linear α,ω‑dicarboxyl‑terminated poly(D,L‑lactide)
- Fully amorphous (non‑crystalline); random D/L‑lactide sequence, no melting point
- Relatively fast, uniform hydrolytic degradation vs higher‑MW PDLLA‑Acid
- Good biocompatibility; degrades into lactic‑acid metabolites
- Dual reactive‑COOH termini, activatable by EDC/NHS for amine‑amide coupling
- Narrow molecular‑weight distribution, consistent batch‑to‑batch performance
- Soluble in DCM, CHCl₃, THF, DMF, acetone; insoluble in water
Applications
- Synthetic precursor for PDLLA‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑functionalized peptides, proteins, targeting ligands and dyes after EDC/NHS activation
- Fabrication of amide‑linked polymer‑drug conjugates for drug‑delivery research
- Carboxyl‑functional surface modification of nanoparticles, microspheres and biodegradable films
- Intermediate for synthesizing degradable polyester and polyurethane biomaterials
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere, keep away from moisture
- Hermetically sealed storage; avoid moisture‑triggered hydrolysis and side‑reactions; prevent repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.