PCL Diacid (HOOC‑PCL‑COOH, MW 5K) is linear α,ω‑dicarboxyl‑terminated biodegradable aliphatic polyester. Compared with 2 K and 3 K PCL Diacid, the 5 kDa polymer shows significantly enhanced hydrophobicity and crystallinity, accompanied by slower hydrolytic degradation rate. Dual terminal carboxylic acid groups can be activated by EDC/NHS reagents to form amide bonds with amine‑containing peptides, proteins and small‑molecule therapeutics. It acts as a versatile bifunctional building block for preparing block copolymers, cross‑linked polymer networks, polymer‑drug conjugates and functional biodegradable biomaterials in biomedical research.
Key Features
- MW: 5000 Da, linear polycaprolactone with carboxyl groups at both chain termini
- Higher hydrophobicity and crystallinity, slower hydrolysis performance versus 2K / 3K PCL Diacid
- Biocompatible semi‑crystalline biodegradable polyester
- Dual reactive‑COOH termini, EDC/NHS‑activatable for amide coupling with amine‑groups
- Narrow molecular weight distribution, excellent batch‑to‑batch repeatability
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water
Applications
- Synthetic precursor for PCL‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins and therapeutic molecules upon EDC/NHS activation
- Fabrication of amide‑linked polymer‑drug conjugates for drug‑delivery research
- Carboxyl‑functional surface modification for biodegradable tissue‑engineering scaffolds
- Intermediate for synthesizing degradable polyurethane and polyester polymers
Handling & Storage
- Store at −20 °C under dry inert nitrogen or argon atmosphere
- Keep hermetically sealed and dry, avoid moisture‑triggered side reactions; prohibit repeated freeze‑thaw cycles
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.