PCL Diacid (HOOC‑PCL‑COOH, MW 2K) is linear bifunctional biodegradable aliphatic polyester, with carboxylic acid groups at both chain termini. The low‑molecular‑weight 2 kDa variant presents moderate hydrophobicity and relatively fast hydrolytic degradation rate. Dual terminal‑COOH groups support amide‑bond formation via EDC/NHS activation, enabling conjugation with amine‑bearing peptides, proteins and small‑molecule drugs. It is a valuable building block for synthesizing block copolymers, cross‑linked networks, polymer‑drug conjugates and surface‑modified biomaterials for biomedical research。
Key Features
- MW: 2000 Da, linear PCL with carboxyl groups at both ends (α,ω‑dicarboxyl terminated)
- Moderate hydrophobicity, relatively rapid hydrolysis compared to higher‑MW PCL‑Diacid
- Biocompatible, semi‑crystalline biodegradable polyester
- Dual reactive‑COOH termini; activatable by EDC/NHS for amide coupling with amines
- Narrow molecular weight distribution, consistent batch‑to‑batch performance
- Soluble in DCM, CHCl₃, THF, DMF; insoluble in water
Applications
- Synthetic precursor for PCL‑based block copolymers and cross‑linked polymer networks
- Bioconjugation with amine‑modified peptides, proteins and therapeutic molecules after EDC/NHS activation
- Synthesis of amide‑linked polymer‑drug conjugates for drug‑delivery research
- Surface carboxylation and functional modification of biodegradable biomaterial substrates
- Intermediate for polyurethane and polyester degradable polymer synthesis
Handling & Storage
- Store at −20 °C under dry, inert nitrogen or argon atmosphere
- Keep sealed and dry, avoid moisture, prevent carboxyl‑group‑triggered side reactions; avoid repeated freeze‑thaw
- For laboratory research only; not for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.