DBCO-PEG13-DBCO
This product is a homobifunctional linker featuring two dibenzocyclooctyne (DBCO) groups connected by a thirteen-unit PEG chain. The DBCO groups enable ultrafast, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides, while the PEG13 spacer provides excellent solubility, flexibility, and extended spacing. This design makes it especially valuable for crosslinking, biomolecule dimerization, and nanomaterial functionalization.
Key Features and Benefits
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Dual DBCO Groups: Supports efficient, copper-free click chemistry with azides.
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PEG13 Spacer: Provides hydrophilicity, flexibility, and long-range spacing.
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Homobifunctional Design: Enables crosslinking or dimerization of azide-modified biomolecules.
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Copper-Free Reaction: Eliminates cytotoxicity concerns for biological systems.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Crosslinking: Joins azide-modified proteins, peptides, or polymers.
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Bioconjugation: Builds multifunctional conjugates for therapeutic or diagnostic use.
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Nanotechnology: Functionalizes nanoparticles, hydrogels, or surfaces with dual DBCO groups.
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Probe Development: Creates crosslinked or dimeric probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use freshly prepared solutions; avoid repeated freeze–thaw cycles.
This product combines dual click reactivity with a flexible PEG13 backbone, specifically offering an efficient tool for bioconjugation, crosslinking, and nanomaterial modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
