Thiol‑Poly(ε‑caprolactone) (PCL‑SH, MW 20K) is monothiol‑terminated high‑molecular‑weight biodegradable poly(ε‑caprolactone). Within the PCL‑SH series, 20 kDa variant exhibits maximum hydrophobicity and crystallinity, accompanied by extremely slow hydrolytic degradation kinetics under physiological conditions. The terminal reactive thiol (-SH) enables thiol‑maleimide click coupling, disulfide‑exchange reaction, and covalent immobilization onto gold‑containing substrates. It is well‑suited for fabricating mechanically robust hydrophobic‑core micelles, nanoparticles, and bulk degradable polymer constructs, widely adopted for ultra‑long‑term sustained‑release drug delivery and tissue‑engineering research.
Key Features
- MW: 20000 Da, single‑end thiol functionalized poly(ε‑caprolactone)
- Highest hydrophobicity and crystallinity among 2K‑20K PCL‑SH product range
- Excellent biocompatibility, ultra‑slow hydrolytic degradation rate
- Reactive terminal thiol for maleimide bioconjugation and gold‑surface anchoring
- Narrow molecular weight distribution, reliable batch‑to‑batch consistency
- Soluble in DCM, CHCl₃, THF; insoluble in aqueous media
Applications
- Fabrication of mechanically robust PCL‑based micelles and nanoparticles for ultra‑long‑term sustained release of hydrophobic drugs
- Bioconjugation with maleimide‑modified peptides, proteins and targeting moieties
- Surface functional modification of gold nanoparticles and gold‑coated biomaterial substrates
- Preparation of redox‑responsive disulfide‑linked polymer‑drug conjugates
- Manufacturing and surface modification of long‑cycle degradable tissue‑engineering scaffolds
Handling & Storage
- Store at −20 °C under inert nitrogen or argon atmosphere
- Maintain dry environment, avoid moisture ingress and repeated freeze‑thaw cycles
- Thiol groups are highly susceptible to oxidation; minimize exposure to ambient air
- For research‑only use; not intended for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.