Thiol‑Poly(ε‑caprolactone) (PCL‑SH, MW 2K) is a monothiol‑terminated poly(ε‑caprolactone) biodegradable polymer. The hydrophobic PCL backbone provides excellent biocompatibility and biodegradability via hydrolysis under physiological conditions. Terminal thiol (‑SH) groups enable facile bioconjugation reactions, including thiol‑maleimide coupling, thiol‑disulfide exchange, and gold‑surface immobilization. This 2 kDa variant offers moderate hydrophobicity, suitable for preparing nanoparticles, micelles and polymer‑drug conjugates for biomedical research.
Key Features
- MW: 2000 Da, monothiol end‑functionalized polycaprolactone
- Hydrophobic, biocompatible and hydrolytically degradable
- Reactive thiol group for conjugation with maleimide, disulfide, gold substrates
- Narrow molecular weight distribution, consistent batch‑to‑batch performance
- Soluble in organic solvents such as DCM, CHCl₃, THF; insoluble in water
Applications
- Fabrication of thiol‑functionalized PCL‑based micelles and nanoparticles for drug delivery
- Bioconjugation with maleimide‑modified peptides, proteins and targeting moieties
- Surface modification of gold nanoparticles and gold‑coated biomaterials
- Synthesis of disulfide‑linked biodegradable polymer‑drug conjugates
- Tissue‑engineering scaffold modification research
Handling & Storage
- Store at −20 °C under inert nitrogen or argon atmosphere
- Keep dry, avoid moisture and repeated freeze‑thaw cycles
- Thiol groups are sensitive to oxidation; minimize exposure to air
- For research use only, not for clinical or diagnostic applications
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.