PLGA N3 Capped, MW 40K is an azide-functionalized poly(lactic-co-glycolic acid) with a molecular weight of approximately 40K. It combines a biodegradable PLGA backbone with terminal azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
Key Features and Benefits
- Azide-Capped PLGA: Combines biodegradable poly(lactic-co-glycolic acid) with terminal azide functionality for selective chemical conjugation.
- MW 40K: Provides a relatively high molecular weight for polymer matrix formation, particle formulation, controlled-release research, and functional biomaterial development.
- Azide Functionality: The terminal –N3 group provides a reactive site specifically for click chemistry with compatible alkyne-functionalized molecules.
- Click Chemistry Platform: Supports copper-catalyzed azide-alkyne cycloaddition (CuAAC) with compatible terminal alkynes for efficient covalent conjugation.
- Copper-Free Conjugation: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctynes such as DBCO and BCN.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform specifically for polymer and drug-delivery research.
- Versatile Functionalization Platform: Terminal azide functionality specifically enables attachment of compatible ligands, polymers, peptides, fluorescent probes, and other alkyne-functionalized molecules.
Applications
- CuAAC Click Chemistry: Enables conjugation with compatible terminal alkyne-functionalized molecules using copper-catalyzed click chemistry.
- Copper-Free Click Chemistry: Supports SPAAC reactions with compatible strained cyclooctynes such as DBCO and BCN.
- Bioconjugation: Enables attachment of compatible biomolecules and functional ligands through azide-based click chemistry.
- Polymer Functionalization: Supports preparation of functional PLGA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Enables modification of PLGA nanoparticles and related polymeric delivery systems with compatible click-reactive molecules.
- Surface Modification: Supports functionalization of PLGA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of click-functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLGA N3 Capped, MW 40K provides a biodegradable PLGA platform with terminal azide functionality for versatile click chemistry and polymer modification and specifically supports CuAAC and copper-free SPAAC conjugation, bioconjugation, nanoparticle functionalization, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.