PLGA N3 Capped, MW 40K (PLGA‑Azide) is a premium ultra-high‑molecular‑weight, azide‑terminated click‑reactive biodegradable PLGA copolymer, representing the highest stability grade in the PLGA-N3 series. Designed for multi-year ultra-long-term bioorthogonal conjugation, high-rigidity implantable nanoparticle systems, and long-acting sustained drug delivery, this polymer features ultra-compact chain entanglement, maximum mechanical toughness and multi-year slow degradation kinetics. It retains stable terminal azide reactivity throughout ultra-long in vivo cycles, making it a top-tier functional building block for translational and implantable biomedical research.
Basic Specifications
Alternative Name: PLGA‑Azide, PLGA‑N3
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑Azide
Molecular Weight: 40K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Terminal Azide (‑N₃) Click Reactivity: Functionalized with high-purity terminal azide groups, enabling highly specific, background-free bioorthogonal click reactions. It stably conjugates with alkyne, DBCO and BCN functional groups via CuAAC or copper-free SPAAC under mild physiological conditions, forming chemically inert triazole linkages. The reactivity remains consistent over multi-year degradation cycles, supporting ultra-long-term biomolecule immobilization and stable in vivo labeling for high-standard biomedical studies.
Top-Tier 40K Ultra-High Molecular Weight Performance: As the highest molecular weight grade of PLGA-N3 polymer, 40K MW forms extremely dense polymer chain entanglement, delivering industry-leading structural rigidity, anti-fatigue performance and morphological stability. It exhibits the slowest, most uniform degradation profile across the entire PLGA-N3 series, completely eliminating particle collapse, structural deformation and premature drug release, perfectly suited for multi-year long-acting delivery and implantable carrier fabrication.
Superior Biocompatibility & Ultra-Mild Degradation: Adopts high-purity biocompatible PLGA backbone, achieving gradual, mild and homogeneous hydrolysis into endogenous non-toxic lactic acid and glycolic acid. No local inflammation, tissue irritation or residual toxicity is generated during the multi-year degradation process, fully complying with clinical-grade biosafety requirements for long-term implantation and translational medical applications.
Multi-Year Permanent Conjugation Stability: Precision terminal N3 capping ensures uniform reactive group distribution and long-term activity retention. The robust triazole covalent bond resists dissociation and functional attenuation during ultra-long polymer erosion, permanently maintaining the bioactivity of conjugated antibodies, proteins, targeting ligands and fluorescent probes throughout the full material lifecycle.
Implantable-Grade Biomedical Adaptability: Featuring maximum mechanical toughness and multi-year degradability, the 40K PLGA-N3 is highly adaptable for ultra-stable implantable nanoparticles, long-service-life hydrogel scaffolds and durable tissue engineering materials. It provides reliable click functionalization capability for high-end long-cycle biomedical and clinical translational research.
Applications
Multi-Year Permanent Bioorthogonal Conjugation: Ideal for ultra-stable covalent modification of high-value therapeutic antibodies, long-acting proteins, polypeptide drugs and DBCO/alkyne functionalized ligands, supporting permanent biomolecule assembly and multi-year persistent biological tracing.
Multi-Year Ultra-Long Sustained Drug Delivery: Exclusively optimized for implantable long-acting drug delivery systems and multi-year controlled-release formulations, solving the cycle limitations of conventional low/medium/high MW PLGA materials, suitable for long-term chronic disease intervention and ultra-long-acting pharmaceutical development.
Implantable-Grade Nanoparticle Functionalization: Serves as a high-rigidity click-reactive precursor for advanced implantable carrier surface engineering, providing ultra-stable azide click sites for post-fabrication ligand modification without compromising long-term in vivo structural stability.
Long-Life Implantable Biomaterial Construction: Widely applied for bioorthogonal functional modification of multi-year degradable hydrogels and implantable tissue engineering scaffolds, supporting the development of high-toughness, long-service-life intelligent biomedical materials and implantable therapeutic devices.
Storage and Handling
Storage: Store at –20 °C in sealed, dry, moisture-proof container. Inert-gas sealing is strongly recommended for long-term preservation to fully retain azide reactivity and polymer structural integrity.
Handling: Avoid moisture, high-temperature exposure and prolonged air contact; avoid repeated freeze-thaw cycles. Avoid strong impact or heating of neat solid azide-functionalized polymer. Handle in accordance with azide-containing material safety guidelines.
PLGA N3 Capped, MW 40K integrates permanent bioorthogonal azide click reactivity, top-tier structural rigidity and multi-year ultra-long degradability, serving as a premium implantable-grade click-reactive biodegradable polymer for multi-year permanent bioconjugation, ultra-long-acting sustained drug delivery and high-durability implantable biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.