PLGA N3 Capped, MW 5K (PLGA‑Azide) is a medium‑molecular‑weight, azide‑terminated click‑reactive biodegradable PLGA copolymer designed for stable bioorthogonal bioconjugation, medium-cycle nanoparticle functionalization, and conventional sustained targeted drug delivery research. Featuring balanced solubility, moderate structural rigidity and steady degradability, this polymer supports universal bioorthogonal click reactions, serving as a mainstream versatile reactive building block for routine biomedical modification and drug delivery formulation development.
Basic Specifications
Alternative Name: PLGA‑Azide, PLGA‑N3
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑Azide
Molecular Weight: 5K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Terminal Azide (‑N₃) Click Reactivity: Functionalized with highly active terminal azide groups, enabling high-selectivity bioorthogonal click conjugation. It efficiently reacts with alkyne, DBCO and BCN functional groups via CuAAC or copper-free SPAAC reactions under mild physiological conditions, forming stable triazole linkages with extremely low non-specific side reactions, perfectly suitable for sensitive biomolecule modification and biological sample labeling.
Balanced 5K Medium Molecular Weight Performance: Standard 5K medium molecular weight achieves an optimal balance of excellent organic solubility and enhanced structural stability compared with low-MW PLGA. It delivers uniform and moderate hydrolytic degradation speed, avoiding excessive burst release and structural instability of low-molecular polymers, fully adapting to conventional medium-cycle sustained drug delivery and stable nanoparticle preparation scenarios.
Excellent Biocompatibility & Biodegradability: Possesses superior physiological biosafety and compatibility, gradually and uniformly hydrolyzing into non-toxic lactic acid and glycolic acid under physiological environments. No inflammatory stimulation or toxic residue is generated, meeting the safety standards for in vitro click conjugation experiments and medium-term in vivo biomedical applications.
Stable and Repeatable Conjugation Performance: Precise terminal N3 capping technology ensures uniform reactive group loading and stable click reaction activity. The formed triazole covalent bond features excellent chemical stability, effectively resisting dissociation during polymer degradation, and maintaining long-term functional stability of conjugated targeting ligands, fluorescent probes and biomolecules.
Universal Biomedical Adaptability: With moderate mechanical properties and degradation cycle, the 5K PLGA-N3 polymer is compatible with various conventional nanoparticle preparation processes, hydrogel modification and biomaterial functionalization, providing stable and reliable click-reactive performance for routine biomedical research.
Applications
Universal Bioorthogonal Click Bioconjugation: Widely applied for stable covalent coupling of alkyne/DBCO-modified proteins, peptides, oligonucleotides, fluorescent probes and targeted ligands, supporting standardized biomolecule labeling and functional assembly research.
Medium-Cycle Sustained Targeted Drug Delivery: Ideal for preparing structurally stable PLGA nanoparticles and microspheres, realizing uniform medium-term sustained drug release and bioorthogonal functionalized targeted delivery, suitable for conventional disease treatment and routine pharmaceutical formulation research.
Stable Nanoparticle Surface Functionalization: Serves as a high-stability click-reactive precursor for biodegradable carrier surface engineering, introducing fixed azide click sites for post-synthesis ligand modification, which does not damage the integrity and morphology of pre-prepared nanoparticles.
Functional Modification of Biomedical Materials: Used for bioorthogonal functional modification of degradable hydrogels and tissue engineering scaffolds, constructing reactive intelligent biomedical interfaces and stable functional biomaterials for medium-cycle tissue engineering research.
Storage and Handling
Storage: Store at –20 °C in sealed, dry, moisture-proof container. Inert-gas sealing is recommended for long-term preservation to retain azide reactivity and polymer structural integrity.
Handling: Avoid moisture, high-temperature exposure and prolonged air contact; avoid repeated freeze-thaw cycles. Avoid strong impact or heating of neat solid azide-functionalized polymer. Handle in accordance with azide-containing material safety guidelines.
PLGA N3 Capped, MW 5K integrates stable bioorthogonal azide click reactivity, balanced structural performance and moderate degradability, serving as a universal standard click-reactive biodegradable polymer for routine bioconjugation, medium-cycle sustained targeted drug delivery and stable biomaterial modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.