PLGA N3 Capped, MW 10K (PLGA‑Azide) is a high‑molecular‑weight, azide‑terminated click‑reactive biodegradable PLGA copolymer engineered for high-stability bioorthogonal bioconjugation, long-cycle nanoparticle functionalization, and prolonged sustained targeted drug delivery research. Featuring enhanced structural rigidity, excellent morphological stability and extended degradation cycle compared with medium and low-MW PLGA, this polymer maintains efficient bioorthogonal click reactivity, serving as a high-performance reactive building block for long-term biomedical modification and sustained-release formulation development.
Basic Specifications
Alternative Name: PLGA‑Azide, PLGA‑N3
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑Azide
Molecular Weight: 10K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Terminal Azide (‑N₃) Click Reactivity: Functionalized with highly active terminal azide groups, enabling high-selectivity bioorthogonal click conjugation. It efficiently reacts with alkyne, DBCO and BCN functional groups via CuAAC or copper-free SPAAC reactions under mild physiological conditions, forming stable triazole linkages with extremely low non-specific side reactions, perfectly suitable for long-term sensitive biomolecule modification and in vivo biological labeling.
Stable 10K High Molecular Weight Performance: Standard 10K high molecular weight forms dense polymer chain entanglement, delivering superior structural rigidity, anti-deformation performance and morphological stability relative to medium and low-MW PLGA. It features uniform and prolonged hydrolytic degradation behavior, effectively preventing particle rupture, structural fatigue and premature drug leakage, fully adapting to long-cycle sustained drug delivery and high-stability nanoparticle preparation scenarios.
Excellent Biocompatibility & Biodegradability: Possesses superior physiological biosafety and compatibility, gradually and uniformly hydrolyzing into non-toxic lactic acid and glycolic acid under physiological environments. No inflammatory stimulation or toxic residue is generated, meeting strict safety standards for long-term in vivo biomedical applications and sustained-release research.
Long-Term Stable Conjugation Performance: Precise terminal N3 capping technology ensures uniform reactive group loading and persistent click reaction activity. The formed triazole covalent bond exhibits excellent chemical stability, resisting dissociation throughout long-term polymer degradation cycles and maintaining stable functional activity of conjugated targeting ligands, fluorescent probes and biomolecules.
High-Stability Biomedical Adaptability: With enhanced mechanical stability and long degradation cycle, the 10K PLGA-N3 polymer is highly compatible with long-acting nanoparticle preparation, durable hydrogel modification and implantable biomaterial functionalization, providing reliable click-reactive performance for long-cycle advanced biomedical research.
Applications
Long-Cycle Bioorthogonal Click Bioconjugation: Widely applied for durable covalent coupling of alkyne/DBCO-modified therapeutic proteins, antibodies, peptides and targeted ligands, supporting long-term stable biomolecule labeling and functional assembly for prolonged biological research.
Prolonged Sustained Targeted Drug Delivery: Ideal for preparing high-stability PLGA nanoparticles and microspheres, realizing uniform long-cycle sustained drug release and bioorthogonal functionalized targeted delivery, suitable for chronic disease treatment and long-acting controlled-release formulation development.
High-Stability Nanoparticle Surface Functionalization: Serves as a high-durability click-reactive precursor for biodegradable carrier surface engineering, introducing stable azide click sites for post-synthesis ligand modification without damaging nanoparticle structural integrity and long-term stability.
Durable Biomedical Material Modification: Used for bioorthogonal functional modification of long-cycle degradable hydrogels and implantable tissue engineering scaffolds, constructing stable intelligent biomedical interfaces and high-durability functional biomaterials for prolonged tissue engineering research.
Storage and Handling
Storage: Store at –20 °C in sealed, dry, moisture-proof container. Inert-gas sealing is recommended for long-term preservation to retain azide reactivity and polymer structural integrity.
Handling: Avoid moisture, high-temperature exposure and prolonged air contact; avoid repeated freeze-thaw cycles. Avoid strong impact or heating of neat solid azide-functionalized polymer. Handle in accordance with azide-containing material safety guidelines.
PLGA N3 Capped, MW 10K integrates persistent bioorthogonal azide click reactivity, high structural stability and long-cycle degradability, serving as a high-performance click-reactive biodegradable polymer for long-term bioconjugation, prolonged sustained targeted drug delivery and durable biomaterial modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.