PLGA N3 Capped, MW 20K (PLGA‑Azide) is an ultra-high‑molecular‑weight, azide‑terminated click‑reactive biodegradable PLGA copolymer designed for ultra-stable bioorthogonal bioconjugation, ultra-long-cycle nanoparticle functionalization, and multi-month sustained targeted drug delivery research. Boasting ultra-rigid polymer structure, exceptional morphological stability and extended slow degradation kinetics superior to medium and conventional high-MW PLGA, this polymer retains highly efficient bioorthogonal click reactivity, acting as a high-end reactive building block for long-term implantable biomedical modification and ultra-long-acting sustained-release formulation development.
Basic Specifications
Alternative Name: PLGA‑Azide, PLGA‑N3
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑Azide
Molecular Weight: 20K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Terminal Azide (‑N₃) Click Reactivity: Modified with highly active terminal azide functional groups, enabling ultra-selective bioorthogonal click conjugation. It efficiently reacts with alkyne, DBCO and BCN moieties via CuAAC or copper-free SPAAC reactions under mild physiological conditions, forming stable, inert triazole linkages with negligible non-specific side reactions. This property perfectly supports ultra-long-term sensitive biomolecule modification and persistent in vivo biological labeling for long-cycle biomedical studies.
Ultra-Stable 20K Ultra-High Molecular Weight Performance: 20K ultra-high molecular weight forms extremely dense polymer chain entanglement, delivering outstanding structural rigidity, anti-deformation capability and morphological durability compared with low and medium-MW PLGA materials. It features uniform, ultra-slow hydrolytic degradation behavior, completely avoiding particle collapse, structural fatigue and premature drug leakage, fully catering to ultra-long-cycle sustained drug delivery and high-rigidity nanoparticle preparation requirements.
Excellent Biocompatibility & Mild Biodegradability: Possesses premium physiological biosafety and tissue compatibility, undergoing mild, uniform hydrolysis into endogenous non-toxic lactic acid and glycolic acid in physiological environments. No inflammatory irritation, tissue damage or toxic residue occurs throughout the entire degradation process, complying with strict safety standards for ultra-long-term in vivo implantation and translational biomedical research.
Ultra-Long Stable Conjugation Performance: Precision terminal N3 capping technology ensures homogeneous reactive group loading and long-lasting click reaction activity. The formed triazole covalent bond features superior chemical stability, resisting dissociation and failure during ultra-long polymer degradation cycles, stably maintaining the biological activity of conjugated targeting ligands, fluorescent probes and functional biomolecules.
Ultra-High Stability Biomedical Adaptability: With extreme mechanical toughness and ultra-long degradation cycle, the 20K PLGA-N3 polymer is perfectly compatible with ultra-stable long-acting nanoparticle fabrication, durable implantable hydrogel modification and long-cycle tissue engineering scaffold functionalization, providing reliable click-reactive performance for high-standard long-term advanced biomedical research.
Applications
Ultra-Long-Cycle Bioorthogonal Click Bioconjugation: Ideal for ultra-durable covalent coupling of alkyne/DBCO-modified antibodies, therapeutic proteins, functional peptides and targeted ligands, supporting persistent biomolecule labeling and stable functional assembly for multi-month long-cycle biological research.
Multi-Month Sustained Targeted Drug Delivery: Optimized for manufacturing high-rigidity PLGA nanoparticles and microspheres, achieving uniform ultra-long-cycle sustained drug release and stable bioorthogonal functionalized targeted delivery, applicable for chronic disease long-acting treatment and ultra-long-term controlled-release formulation development.
Ultra-Stable Nanoparticle Surface Functionalization: Serves as a high-durability click-reactive precursor for advanced biodegradable carrier surface engineering, providing stable azide click sites for post-synthesis ligand modification without impairing nanoparticle structural integrity and ultra-long-term in vivo stability.
Long-Duration Implantable Biomedical Material Modification: Applied for bioorthogonal functional modification of ultra-long-cycle degradable hydrogels and implantable tissue engineering scaffolds, constructing high-stability intelligent biomedical interfaces and ultra-durable functional biomaterials for long-term tissue engineering and implantable device research.
Storage and Handling
Storage: Store at –20 °C in sealed, dry, moisture-proof container. Inert-gas sealing is strongly recommended for long-term preservation to fully retain azide reactivity and polymer structural integrity.
Handling: Avoid moisture, high-temperature exposure and prolonged air contact; avoid repeated freeze-thaw cycles. Avoid strong impact or heating of neat solid azide-functionalized polymer. Handle in accordance with azide-containing material safety guidelines.
PLGA N3 Capped, MW 20K integrates ultra-stable bioorthogonal azide click reactivity, extreme structural rigidity and ultra-long-cycle degradability, serving as a high-end click-reactive biodegradable polymer for ultra-long-term bioconjugation, multi-month sustained targeted drug delivery and ultra-durable implantable biomaterial modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.