PLGA NHS Capped, MW 2K is an NHS ester-functionalized poly(lactic-co-glycolic acid) with a molecular weight of approximately 2K. It combines a low-molecular-weight, biodegradable PLGA backbone with terminal NHS ester functionality specifically for amine-reactive conjugation, bioconjugation, polymer functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- NHS-Capped PLGA: Combines biodegradable poly(lactic-co-glycolic acid) with terminal NHS ester functionality for efficient chemical conjugation.
- MW 2K: Provides a low molecular weight with high relative end-group content and good processability specifically for conjugation, polymer modification, and formulation research.
- Amine-Reactive Functionality: The terminal NHS ester reacts with compatible primary amines to form stable amide linkages under appropriate reaction conditions.
- Direct Conjugation Platform: The activated NHS ester enables amine coupling without requiring a separate carboxyl-group activation step.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that support gradual polymer degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform for polymer and drug-delivery research.
- Good Processability: The low molecular weight specifically facilitates polymer dissolution, formulation, particle preparation, and chemical functionalization compared with higher-molecular-weight PLGA grades.
- Versatile Functionalization Platform: NHS functionality specifically enables conjugation with compatible amine-containing peptides, proteins, ligands, polymers, and other functional molecules.
Applications
- Amine Conjugation: Supports reaction with primary amine-containing molecules to form stable amide bonds.
- Bioconjugation: Enables attachment of compatible peptides, proteins, ligands, and other amine-containing biomolecules.
- Polymer Functionalization: Supports preparation of functional PLGA derivatives and more complex polymer architectures.
- Nanoparticle Functionalization: Supports functionalization of biodegradable PLGA nanoparticles and related polymeric delivery systems.
- Ligand Conjugation: Enables attachment of compatible amine-containing targeting ligands and functional molecules.
- Surface Modification: Supports incorporation of functional components into PLGA-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: NHS esters are moisture sensitive and can hydrolyze in the presence of water. Keep the material dry and minimize exposure to humid air. Allow the material to equilibrate to room temperature before opening to reduce moisture condensation.
PLGA NHS Capped, MW 2K provides a low-molecular-weight biodegradable PLGA platform with terminal NHS ester functionality for efficient amine-reactive conjugation. Its low molecular weight and relatively high end-group content make it useful for polymer functionalization, bioconjugation, nanoparticle modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.