PLGA Cy3 Capped, MW 20K is an ultra-high-molecular-weight fluorescent biodegradable PLGA copolymer with terminal Cy3 fluorophore labeling. Available in 50:50, 65:35, 75:25, 85:15 and custom lactide-glycolide ratios, it is engineered for ultra-stable long-cycle fluorescence tracking, long-term in vivo carrier tracing, and high-stability fluorescent nanoparticle formulation research.
Key Features and Benefits
Cy3 Fluorescent Capped: Functionalized with terminal Cy3 red-orange fluorophores, delivering bright, stable, and long-lasting fluorescent signals. Enables label-free real-time tracking and quantitative detection without additional staining, maintaining intact fluorescence during prolonged polymer degradation.
Lactide Ratio Available: Provides standard ratios of 50:50, 65:35, 75:25, 85:15 and custom customizable formulations. Precisely adjusts polymer hydrophobicity, mechanical strength, and degradation cycle to meet ultra-long-cycle biomedical experimental and formulation requirements.
MW 20K: Ultra-high molecular weight forms dense polymer chain entanglement, delivering exceptional structural rigidity and particle stability. Compared with low and medium MW PLGA, it features significantly extended degradation time, resisting particle deformation and drug leakage, ideal for ultra-long sustained-release fluorescent carrier preparation.
Biocompatible & Biodegradable: Possesses excellent biological safety, completely hydrolyzing into non-toxic lactic acid and glycolic acid under physiological conditions. Suitable for long-term in vivo imaging and prolonged biological tracking applications.
Fluorescence Stable & Reliable: Precise terminal capping technology prevents fluorophore shedding and fluorescence quenching, retaining consistent, high-sensitivity fluorescent signals throughout long-term circulation and slow degradation processes.
Applications
Ultra-Long-Term Particle Tracing: Designed for prolonged in vitro and in vivo tracking, observing tissue distribution, circulation retention and metabolic behavior of PLGA nanoparticles and microspheres.
Long-Cycle Sustained Drug Delivery Imaging: Supports visual monitoring of slow-release drug carrier degradation, drug release kinetics, and in vivo accumulation for long-acting formulation development.
Stable Biomedical Fluorescent Labeling: Serves as a high-stability self-fluorescent polymer matrix for long-term degradable biomaterial imaging and biological distribution analysis.
High-Stability Formulation Research: Ideal for evaluating long-term particle structural stability, anti-leakage performance, and sustained delivery efficiency of advanced long-acting drug delivery systems.
Storage and Handling
Storage: Store at –20 °C in a sealed, dry, light-proof and moisture-proof container.
Handling: Avoid strong light exposure, repeated freeze-thaw cycles and high temperature environments to prevent fluorescence quenching and polymer hydrolysis, ensuring long-term sample and signal stability.
PLGA Cy3 Capped, MW 20K integrates ultra-high-molecular-weight structural stability, long-cycle degradability, and high-stability Cy3 fluorescent labeling, exclusively optimized for ultra-long-term visual tracking, stable sustained-release imaging, and high-performance biodegradable carrier research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.