Poly(L-Ornithine)-PEG-N3, MW x 5K, n 2K is a functional block copolymer composed of poly(L-ornithine) (PLO) and polyethylene glycol (PEG) with a terminal azide (N3) group. This grade combines approximately 5K PLO with 2K PEG, providing a PLO-rich architecture with amine and azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines amine-functional PLO with hydrophilic PEG and terminal azide functionality for polymer modification and conjugation.
- PLO MW 5K: Provides a poly(amino acid) segment with pendant primary amine groups for molecular interactions and chemical modification.
- PEG MW 2K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and interfacial stabilization.
- PLO-Rich Architecture: The 2.5:1 PLO-to-PEG molecular weight ratio favors amine-functional PLO content while retaining a hydrophilic PEG component.
- Azide Functionality: Provides a terminal N3 group for click chemistry with compatible alkyne-functional molecules.
- Amine-Functional Polymer: The PLO block provides pendant primary amine groups for ionic interactions, chemical modification, and conjugation.
- Versatile Conjugation Platform: Combines terminal azide functionality with pendant amine groups to support multiple strategies for polymer modification and bioconjugation.
Applications
- CuAAC Click Chemistry: Supports copper-catalyzed azide-alkyne cycloaddition with terminal alkyne-functional molecules.
- Copper-Free Click Chemistry: Supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctyne groups.
- Bioconjugation: Enables attachment of peptides, proteins, ligands, and other biomolecules through azide-based click chemistry or amine-reactive coupling.
- Polymer Functionalization: Provides azide and primary amine groups for attachment of functional molecules and preparation of polymer conjugates.
- Drug Delivery: Supports development of functional polymer systems and modified drug-delivery carriers.
- Ionic Complex Formation: Provides amine-containing PLO segments for electrostatic interactions with negatively charged molecules and materials.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for conjugates, coatings, hydrogels, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines amine-functional PLO, hydrophilic PEG, and terminal azide functionality in a PLO-rich block copolymer. It specifically supports click chemistry, bioconjugation, polymer functionalization, drug delivery, ionic complex formation, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
