Poly(L-Glutamic acid)-mPEG, MW x 3K, n 5K is a functional block copolymer composed of poly(L-glutamic acid) (pGlu) and methoxy polyethylene glycol (mPEG). This grade combines approximately 3K pGlu with 5K mPEG, providing an mPEG-rich architecture with pendant carboxyl groups and a substantial hydrophilic PEG segment specifically for polymer functionalization, bioconjugation, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines carboxyl-functional pGlu with hydrophilic mPEG for polymer modification, conjugation, drug delivery, and biomaterial development.
- pGlu MW 3K: Provides a poly(amino acid) segment with pendant carboxyl groups for molecular interactions and chemical modification.
- mPEG MW 5K: Provides a substantial hydrophilic segment for aqueous compatibility, hydration, and steric stabilization.
- mPEG-Rich Architecture: The 3:5 pGlu-to-mPEG molecular weight ratio favors hydrophilic PEG character while retaining substantial carboxyl-functional pGlu content.
- Carboxyl-Functional Polymer: The pGlu block provides pendant carboxyl groups that support ionic interactions, chemical modification, and conjugation.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy PEG terminus while the pGlu block supplies functional sites for further modification.
- Functionalizable Polymer Platform: Enables modification of pGlu carboxyl groups and coupling with amine-containing molecules using established carboxyl activation chemistries such as EDC/NHS.
Applications
- Polymer Functionalization: Provides pendant carboxyl groups for chemical modification and attachment of functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, ligands, and other biomolecules through activated carboxyl groups.
- Drug Delivery: Supports development of functional polymer systems and polymer-drug conjugates.
- Ionic Complex Formation: Provides carboxyl-containing pGlu segments for electrostatic interactions with positively charged molecules and materials.
- Surface Modification: Supports attachment of functional molecules and development of modified polymeric surfaces.
- Polymer Conjugates: Enables preparation of PEG-poly(amino acid) conjugates with drugs, peptides, targeting ligands, and other functional molecules.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials for coatings, conjugates, hydrogels, and related applications.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines carboxyl-functional pGlu with a substantial hydrophilic mPEG segment in an mPEG-rich architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
