mPEG-Poly(L-Aspartic Acid) (mPEG-pAsp), MW x 7.5K, n 2K is a functional block copolymer composed of methoxy polyethylene glycol (mPEG) and poly(L-aspartic acid) (pAsp). This grade combines approximately 7.5K mPEG with 2K pAsp, providing a strongly mPEG-rich architecture with a substantial hydrophilic PEG segment and multiple carboxyl groups specifically for chemical modification, molecular interactions, drug delivery, and biomaterial development.
Key Features and Benefits
- Functional Block Copolymer: Combines hydrophilic mPEG with carboxyl-rich pAsp for drug delivery, bioconjugation, and biomaterial development.
- mPEG MW 7.5K: Provides a substantial hydrophilic segment for aqueous compatibility, hydration, and steric stabilization.
- pAsp MW 2K: Provides a poly(amino acid) segment with pendant carboxyl groups for molecular interactions and chemical modification.
- mPEG-Rich Architecture: The 3.75:1 mPEG-to-pAsp molecular weight ratio strongly favors hydrophilic PEG character while retaining a functional pAsp component.
- Carboxyl-Rich Polymer: The pAsp segment provides pendant carboxyl groups for conjugation, ionic interactions, and further chemical functionalization.
- Methoxy-Terminated PEG: The nonreactive methoxy end group provides a stable PEG terminus while the pAsp segment supplies functional sites for modification.
- Functionalizable Polymer Platform: Supports modification of pAsp carboxyl groups with amine-containing molecules through coupling strategies such as EDC/NHS chemistry.
Applications
- Polymer Functionalization: Provides carboxyl groups for chemical modification and attachment of suitable functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, targeting ligands, and other molecules through carboxyl-group chemistry.
- Drug Delivery: Supports development of functional polymer-based drug delivery and carrier systems.
- Ionic Complex Formation: The carboxyl-containing pAsp segment can participate in electrostatic interactions with positively charged molecules and ions.
- Surface Modification: Supports functionalization of nanoparticles, coatings, and other biomaterial surfaces.
- Polymer Conjugates: Supports development of functional polymer-drug, polymer-peptide, and other molecular conjugates.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials, conjugates, delivery systems, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines a substantial hydrophilic mPEG block with a functional pAsp segment in a strongly mPEG-rich block copolymer architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
