PCL-PEG-NHS is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and an NHS ester terminal group. This grade contains approximately 3K PCL and 5K PEG blocks while the NHS functionality enables efficient conjugation with primary amines.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for especially versatile drug delivery and biomaterial applications.
- PCL MW 3K: Provides a biodegradable hydrophobic segment especially suitable for encapsulation and polymer assembly.
- PEG MW 5K: Provides a hydrophilic segment that supports aqueous compatibility and steric stabilization.
- NHS Functionalization: Provides an activated ester for efficient reaction with primary amines.
- Amine-Reactive: Enables coupling with peptides, proteins, ligands, and other amine-containing molecules.
- Biodegradable PCL Segment: PCL undergoes hydrolytic degradation through cleavage of its ester bonds.
Applications
- Bioconjugation: Enables coupling with amine-containing peptides, proteins, and targeting ligands.
- Nanoparticle Research: Supports development of functional polymeric nanoparticles and nanocarriers.
- Drug Delivery: Supports formulation of amphiphilic carriers for hydrophobic compounds.
- Surface Functionalization: Enables introduction of targeting ligands and other functional molecules.
- Biomaterial Research: Supports development of functional polymer assemblies and biodegradable material systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture. NHS esters are moisture-sensitive and can hydrolyze in aqueous environments.
PCL-PEG-NHS, MW x 3K, n 5K combines biodegradable PCL, hydrophilic PEG, and amine-reactive NHS functionality. It specifically supports bioconjugation, nanoparticle development, drug delivery, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.