PCL-PEG-NHS is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal NHS ester. This grade combines approximately 3K PCL with 1K PEG while its amine-reactive NHS group supports bioconjugation and functional drug delivery systems.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for self-assembly and biomaterial applications.
- PCL MW 3K: Provides the dominant hydrophobic segment specifically for polymer assembly and hydrophobic drug incorporation.
- PEG MW 1K: Provides a shorter hydrophilic segment for interfacial stabilization and functional material design.
- NHS Functionalization: Provides an activated ester for especially efficient reaction with primary amines.
- Amine-Reactive: Enables conjugation with peptides, proteins, targeting ligands, and other amine-containing molecules.
- Biodegradable PCL Segment: PCL undergoes hydrolytic degradation through cleavage of its ester bonds.
Applications
- Bioconjugation: Enables covalent attachment of amine-containing peptides, proteins, and targeting ligands.
- Nanoparticle Research: Supports functionalized nanoparticles and amphiphilic polymer assemblies.
- Drug Delivery: Supports carrier systems for hydrophobic compounds and targeted delivery research.
- Surface Functionalization: Enables attachment of targeting ligands and other functional molecules.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. NHS ester groups are moisture-sensitive and susceptible to hydrolysis.
PCL-PEG-NHS, MW x 3K, n 1K combines a relatively large hydrophobic PCL block with a shorter PEG segment while its terminal NHS group provides a convenient route for amine-selective functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.