PCL-PEG-NHS is an amphiphilic block copolymer specifically containing poly(ε-caprolactone), polyethylene glycol, and an NHS ester terminal group. This grade contains approximately 3K PCL and 2K PEG blocks while the NHS functionality provides an activated site for conjugation with primary amines.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for drug delivery and biomaterial applications.
- PCL MW 3K: Provides a biodegradable hydrophobic segment for polymer assembly and hydrophobic drug incorporation.
- PEG MW 2K: Provides a hydrophilic segment for aqueous compatibility and steric stabilization.
- NHS Functionalization: Provides an activated ester for especially efficient reaction with primary amines.
- Amine-Reactive: Enables coupling with peptides, proteins, targeting ligands, and other amine-containing molecules.
- Biodegradable PCL Segment: PCL undergoes hydrolytic degradation through cleavage of its ester bonds.
Applications
- Bioconjugation: Enables coupling with amine-containing peptides, proteins, and targeting ligands.
- Nanoparticle Research: Supports development of functional polymeric nanoparticles and nanocarriers.
- Drug Delivery: Supports amphiphilic carrier systems for hydrophobic compounds.
- Surface Functionalization: Enables attachment of targeting ligands and other functional molecules.
- Biomaterial Research: Supports functional polymer assemblies and biodegradable material systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. NHS ester groups are moisture-sensitive and susceptible to hydrolysis.
PCL-PEG-NHS, MW x 3K, n 2K combines biodegradable PCL, hydrophilic PEG, and amine-reactive NHS functionality that specifically supports bioconjugation, nanoparticle development, drug delivery, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.