PCL-PEG-NHS, MW x 1K, n 5K is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal NHS ester. This grade combines approximately 1K PCL with 5K PEG while its PEG-rich architecture provides strong hydrophilic character, while NHS functionality enables amine-selective conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and biomaterial applications.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for molecular assembly and hydrophobic interactions.
- PEG MW 5K: Provides a dominant hydrophilic segment for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The high PEG-to-PCL ratio specifically favors hydrophilic character and surface stabilization.
- NHS Functionalization: Provides an activated ester for especially efficient reaction with primary amines.
- Amine-Reactive: Enables conjugation with peptides, proteins, targeting ligands, and other amine-containing molecules.
Applications
- Bioconjugation: Enables covalent attachment of amine-containing peptides, proteins, and targeting ligands.
- Nanoparticle Functionalization: Supports PEG-rich surfaces and functionalized polymeric nanocarriers.
- Drug Delivery: Supports amphiphilic delivery systems and surface-functionalized drug carriers.
- Surface Modification: Enables PEGylation and attachment of targeting or recognition molecules.
- Biomaterial Research: Supports development of functional polymer assemblies and biodegradable material systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. NHS ester groups are moisture-sensitive and susceptible to hydrolysis.
PCL-PEG-NHS, MW x 1K, n 5K combines a short PCL block with a substantially longer PEG segment. This architecture is especially useful for PEG-rich polymer systems requiring terminal amine-reactive functionality.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.