PCL-PEG-NH2, MW x 2K, n 3K is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 2K PCL with 3K PEG. Its PEG-rich architecture supports hydrophilic stabilization, while the NH2 group enables conjugation and further functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 2K: Provides a biodegradable hydrophobic segment specifically for core formation and hydrophobic drug incorporation.
- PEG MW 3K: Provides a hydrophilic segment for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The higher PEG-to-PCL ratio specifically favors hydrophilic character and surface stabilization.
- Amine Functionalization: Provides a terminal primary amine for conjugation and chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of peptides, targeting ligands, probes, and other functional molecules.
- Nanoparticle Research: Supports functionalized nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric nanocarriers and delivery of hydrophobic compounds.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and terminal amine functionality.
PCL-PEG-NH2, MW x 2K, n 3K combines biodegradable PCL with a longer PEG segment and terminal amine functionality that specifically supports stabilized polymer assemblies, bioconjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.