PCL-PEG-NH2, MW x 10K, n 1K is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 10K PCL with 1K PEG while its strongly PCL-rich architecture favors hydrophobic assembly, while the NH2 group enables further functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines a dominant hydrophobic PCL block with a shorter hydrophilic PEG segment.
- PCL MW 10K: Provides a substantial biodegradable hydrophobic block for core formation and hydrophobic drug incorporation.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface functionality.
- PCL-Rich Architecture: The 10:1 PCL-to-PEG molecular-weight ratio provides strongly hydrophobic character.
- Amine Functionalization: Provides a terminal primary amine specifically for conjugation and chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of targeting ligands, peptides, probes, and other functional molecules.
- Nanoparticle Research: Supports functionalized nanoparticles, micelles, and other amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carrier systems for hydrophobic compounds and controlled-release research.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and amine functionality.
PCL-PEG-NH2, MW x 10K, n 1K combines a dominant PCL block with short PEG and terminal amine functionality that specifically supports hydrophobic polymer assemblies, bioconjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.