PCL-PEG-NH2, MW x 5K, n 5K is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 5K PCL with 5K PEG while its balanced block architecture supports amphiphilic assembly, while the NH2 group enables further functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG specifically for polymer assembly and drug delivery applications.
- PCL MW 5K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 5K: Provides a hydrophilic segment for aqueous compatibility and steric stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights provide balanced hydrophobic and hydrophilic character.
- Amine Functionalization: Provides a terminal primary amine specifically for conjugation and chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of peptides, targeting ligands, probes, and other functional molecules.
- Nanoparticle Research: Supports functionalized nanoparticles, micelles, and other amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted delivery research.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and terminal amine functionality.
PCL-PEG-NH2, MW x 5K, n 5K combines balanced hydrophobic PCL and hydrophilic PEG blocks with terminal amine functionality that specifically supports amphiphilic assembly, bioconjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.