PCL-PEG-NH2 is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 1K PCL with 2K PEG and its PEG-rich architecture supports hydrophilic stabilization, while the NH2 group enables conjugation and further functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment specifically for molecular assembly and hydrophobic interactions.
- PEG MW 2K: Provides a longer hydrophilic segment for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 2:1 PEG-to-PCL ratio specifically favors hydrophilic character and surface stabilization.
- Amine Functionalization: Provides a terminal primary amine for conjugation and chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of peptides, targeting ligands, probes, and other functional molecules.
- Nanoparticle Functionalization: Supports PEG-rich surfaces and functionalized polymeric nanocarriers.
- Drug Delivery: Supports amphiphilic delivery systems and surface-functionalized drug carriers.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and terminal amine functionality.
PCL-PEG-NH2, MW x 1K, n 2K combines a short PCL block with a longer PEG segment and terminal amine functionality that specifically supports hydrophilic stabilization, bioconjugation, functionalized nanocarriers, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.