PCL-PEG-NH2, MW x 10K, n 3K is an amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal primary amine. This grade combines approximately 10K PCL with 3K PEG while its PCL-rich architecture supports hydrophobic assembly, while the NH2 group provides a reactive site for functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG specificallyfor polymer assembly and drug delivery applications.
- PCL MW 10K: Provides a substantial biodegradable hydrophobic block for core formation and hydrophobic drug incorporation.
- PEG MW 3K: Provides a hydrophilic segment for aqueous compatibility and interfacial stabilization.
- PCL-Rich Architecture: The high PCL-to-PEG ratio favors hydrophobic interactions and amphiphilic self-assembly.
- Amine Functionalization: Provides a terminal primary amine specifically for conjugation and further chemical modification.
- Reactive NH2 Group: Supports coupling with NHS esters, activated carboxyl groups, and other amine-reactive molecules.
Applications
- Bioconjugation: Enables attachment of peptides, ligands, probes, and other functional molecules through the terminal amine.
- Nanoparticle Research: Supports functionalized nanoparticles, micelles, and other amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Surface Functionalization: Provides a reactive amine for introducing targeting ligands and functional groups.
- Biomaterial Research: Supports development of functional and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and terminal amine functionality.
PCL-PEG-NH2, MW x 10K, n 3K combines a dominant hydrophobic PCL block with PEG and terminal amine functionality that specifically supports self-assembly, bioconjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.