Methyltetrazine-PEG24-DBCO is an advanced, bifunctional bioconjugation linker designed for selective and efficient coupling reactions. This linker combines the superior reactivity of methyltetrazine, a bioorthogonal click chemistry handle, with the exceptional hydrophilicity of a 24-unit polyethylene glycol (PEG) chain and the robust copper-free click chemistry moiety, DBCO. This unique combination enables precise and stable conjugation of biomolecules while minimizing non-specific binding.
In pharmaceutical research and development, Methyltetrazine-PEG24-DBCO serves as a powerful tool for creating targeted drug delivery systems, bioimaging probes, and diagnostic assays. Its dual click chemistry handles facilitate rapid, site-specific conjugation of therapeutic agents or imaging agents to biomolecules, such as antibodies, proteins, or peptides. By enhancing solubility, stability, and biocompatibility, this linker significantly improves pharmacokinetic properties, reduces immunogenicity, and facilitates targeted delivery, which ultimately enables the development of more effective and safer therapeutics and diagnostics.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
