Mal-C6-NHS Ester (CAS: 55750-63-5)
Mal-C6-NHS Ester is a cross-linking reagent used in bioconjugation and molecular research. Its maleimide group binds thiol-containing biomolecules like cysteine, while its NHS ester attaches to primary amines such as lysine. Furthermore, the six-carbon hexanoic acid spacer adds flexibility and reduces steric hindrance, making it ideal for protein modification and drug development.
Key Features:
- Reactive Groups:
- Maleimide: Selectively couples with thiol groups, enabling precise and stable conjugation with proteins and peptides.
- NHS Ester: Forms strong amide bonds by reacting with primary amines, ensuring robust molecular attachment.
- Hexanoic Acid Spacer:
- The six-carbon linker enhances molecular flexibility and reduces steric interference, allowing for efficient bioconjugation.
Applications:
- Bioconjugation:
- Attaches biomolecules such as peptides, proteins, and antibodies by coupling thiol and amine-reactive groups.
- Hapten-Carrier Conjugation:
- Crosslinks haptens to carrier proteins or enzymes to antibodies, supporting immunoassays, diagnostics, and vaccine development.
Handling and Storage:
- Molecular Formula: C₁₄H₁₆N₂O₆
- Molecular Weight: 308.29 g/mol
- Storage Recommendations:
- Store at -20°C in a cool, dry environment, away from light and moisture, to preserve stability.
Overall, Mal-C6-NHS Ester offers exceptional versatility in molecular assembly and bioconjugation. Its dual-reactive design and extended carbon linker make it significantly indispensable for advanced research, drug development, and diagnostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
