Mal-C11-NHS Ester (CAS: 87981-04-2)
Mal-C11-NHS Ester, also known as N-Succinimidyl 11-(maleimido)undecanoate, functions as a bifunctional linker designed for bioconjugation and molecular assembly. Its structure includes a maleimide group that specifically reacts with thiol groups (-SH), forming stable thioether bonds. Simultaneously, its NHS ester efficiently couples with primary amines, creating strong amide bonds. The 11-carbon alkyl spacer enhances molecular flexibility, making it ideal for linking proteins, peptides, and other biomolecules.
Key Features:
- Reactive Groups:
- Maleimide: Targets thiol-containing biomolecules, enabling selective and stable conjugation.
- NHS Ester: Couples easily with primary amines, forming strong amide bonds with lysine residues or N-terminal amines.
- Alkyl Spacer:
- The 11-carbon chain improves flexibility and minimizes steric interference during conjugation reactions, supporting more efficient molecular linking.
Applications:
- Bioconjugation:
- Links biomolecules such as peptides, proteins, and antibodies through its thiol and amine-reactive groups, ensuring stable and durable molecular assemblies.
- PROTAC Synthesis:
- Serves as a crucial linker in developing proteolysis-targeting chimeras (PROTACs), which facilitate targeted protein degradation via the ubiquitin-proteasome pathway.
Handling and Storage:
- Molecular Formula: C₁₉H₂₆N₂O₆
- Molecular Weight: 378.42 g/mol
- Storage Recommendations:
- Store at 2-8°C in a dry, dark place, away from light and moisture, to maintain long-term stability.
Mal-C11-NHS Ester enables precise and efficient bioconjugation due to its dual-reactive design and extended alkyl spacer. Its wide-ranging applications in chemical biology, drug development, and PROTAC synthesis make it a vital component in modern molecular research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
