DBCO-PEG4-DBCO
This product is a high-purity homobifunctional linker with two dibenzocyclooctyne (DBCO) groups for copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) click chemistry. The PEG4 spacer improves solubility, flexibility, and reduces steric hindrance, enabling highly efficient, orthogonal bioconjugation specifically in aqueous and organic systems.
Key Features and Benefits
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Dual DBCO Groups – Allow rapid, copper-free click chemistry with azide-containing molecules
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PEG4 Spacer – Enhances solubility and reduces steric interference for optimal reaction efficiency
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Copper-Free Reactivity – Suitable for live-cell and in vivo labeling without metal catalysts
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Orthogonal Chemistry – Supports selective and site-specific modifications
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High Purity – >95% purity ensures consistent performance
Applications
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Crosslinking azide-modified biomolecules
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Antibody and protein modification
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Nanoparticle and hydrogel functionalization
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Bioconjugate and drug delivery system development
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In vivo imaging and labeling studies
Storage and Handling
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Store at –20 °C, dry, and protected from light
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Use anhydrous solvents such as DMSO or DMF
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Avoid prolonged exposure to moisture and heat
This product is a homobifunctional linker with two DBCO groups for SPAAC click chemistry, connected by a PEG4 spacer specifically for solubility and flexibility, enabling efficient bioconjugation without copper catalysts.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
