4-Arm PLGA-N3, MW 40K is a biodegradable branched PLGA polymer with four terminal azide groups and an approximate molecular weight of 40 kDa. Its multivalent architecture specifically supports click chemistry, bioconjugation, crosslinking, drug delivery, and biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Creates a branched structure with four functional PLGA arms.
- Azide Functionalization: Provides terminal azide groups for selective bioorthogonal conjugation.
- MW 40K: Supports durable polymer networks and sustained-release formulations.
- Click Reactivity: Azide groups react with alkynes or strained cyclooctynes through CuAAC or copper-free SPAAC chemistry.
- Multivalent Platform: Four azide groups specifically support efficient conjugation, crosslinking, and multifunctional polymer modification.
Applications
- Click Chemistry: Couples with alkyne- or DBCO-functionalized molecules for selective conjugation.
- Bioconjugation: Attaches peptides, proteins, ligands, dyes, and other functional molecules through click reactions.
- Drug Delivery: Supports biodegradable controlled and sustained-release carrier systems.
- Crosslinking: Forms functional polymer networks with complementary click-reactive compounds.
- Biomaterials: Supports hydrogels, nanoparticles, scaffolds, coatings, and other biodegradable materials.
Storage and Handling
- Storage: Store at –20 °C in a sealed, dry container.
- Handling: Protect from moisture and excessive heat to limit premature hydrolysis and polymer degradation.
4-Arm PLGA-N3, MW 40K combines biodegradable PLGA with four azide groups to specifically support bioorthogonal click chemistry, multivalent bioconjugation, crosslinking, drug delivery, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.