4-Arm PLGA-N3, MW 10K is a branched, biodegradable PLGA polymer with four terminal azide groups. Its low molecular weight and multivalent architecture specifically support click chemistry, bioconjugation, crosslinking, drug delivery, and functional biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Provides four PLGA arms for multivalent functionalization and network formation.
- Azide Functionalization: Supplies terminal azide groups for selective bioorthogonal conjugation.
- MW 10K: Offers low molecular weight for efficient processing, conjugation, and formulation development.\
- Click Reactivity: Azide groups react with alkynes through CuAAC or strained cyclooctynes through SPAAC.
- Multivalent Platform: Four reactive termini enable especially efficient conjugation and multifunctional polymer modification.
- Biodegradable: The PLGA segments undergo hydrolytic degradation into lactic acid and glycolic acid.
Applications
- Click Chemistry: Couples with alkyne- or cyclooctyne-functionalized molecules through selective click reactions.
- Bioconjugation: Attaches peptides, proteins, ligands, dyes, and other functional molecules.
- Crosslinking: Builds biodegradable polymer networks using complementary click-reactive components.
- Drug Delivery: Supports functional carriers, nanoparticles, and controlled-release systems.
- Biomaterials: Enables development of hydrogels, scaffolds, coatings, and other functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a fully sealed container under dry and dark conditions.
- Handling: Protect from moisture, light, and excessive heat to maintain polymer integrity and performance.
4-Arm PLGA-N3, MW 10K combines biodegradable PLGA with four reactive azide termini while its branched structure specifically supports multivalent click chemistry, crosslinking, bioconjugation, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.