Mal-PEG-HZ, MW 3.4K (Maleimide-PEG-Hydrazide) consists of a PEG chain with two functional groups, a maleimide group and a hydrazide group, attached to each end of the chain.
The maleimide group is known for its ability to react with thiol-containing molecules, such as cysteine residues in proteins, to form stable covalent bonds. The hydrazide group, on the other hand, can react with carbonyl groups, such as those found in aldehydes and ketones, to form hydrazone linkages.
Mal-PEG-HZ, MW 3.4K (Maleimide-PEG-Hydrazide) has been utilized in the development of novel drug delivery systems, such as antibody-drug conjugates (ADCs). ADCs are a type of targeted therapy that combines the specificity of an antibody with the potency of a cytotoxic drug.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.