4-Arm PLGA-N3, MW 20K is a branched, biodegradable PLGA polymer with four terminal azide groups while its multivalent architecture specifically supports click chemistry, bioconjugation, crosslinking, drug delivery, and functional biomaterial development.
Key Features and Benefits
- 4-Arm Architecture: Provides four PLGA arms for multivalent functionalization and network formation.
- Azide Functionalization: Supplies terminal azide groups specifically for selective bioorthogonal conjugation.
- MW 20K: Balances polymer processability with efficient conjugation and network formation.
- Click Reactivity: Azide groups react with alkynes through CuAAC or strained cyclooctynes through SPAAC.
- Multivalent Platform: Four reactive termini enable efficient conjugation and multifunctional polymer modification.
- Biodegradable: The PLGA segments undergo hydrolytic degradation into lactic acid and glycolic acid.
Applications
- Click Chemistry: Couples with alkyne- or cyclooctyne-functionalized molecules through selective click reactions.
- Bioconjugation: Attaches peptides, proteins, ligands, dyes, and other functional molecules.
- Crosslinking: Builds biodegradable polymer networks using complementary click-reactive components.
- Drug Delivery: Supports functional carriers, nanoparticles, and controlled-release systems.
- Biomaterials: Enables development of hydrogels, scaffolds, coatings, and other functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a fully sealed container under dry and dark conditions.
- Handling: Protect from moisture, light, and excessive heat to maintain polymer integrity and performance.
4-Arm PLGA-N3, MW 20K combines biodegradable PLGA with four reactive azide termini. Its branched structure specifically supports multivalent click chemistry, crosslinking, bioconjugation, and advanced biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.