Azide-PEG-NHS

Azide-PEG-NHS(N3-PEG-SC) is a versatile compound that has gained significant attention in the field of pharmaceutical research and development due to its unique functional groups and diverse range of applications. Azide-PEG-NHS is a derivative of polyethylene glycol (PEG) that is modified with azide and N-hydroxysuccinimide (NHS) functional groups.

Azide-PEG-NHS is primarily used as a crosslinker for biomolecules, such as proteins, peptides, and antibodies, in order to create stable conjugates. The azide group allows for the conjugation of a wide range of functional groups, such as alkyne, cyclooctyne, and strained cyclooctyne, via click chemistry. Meanwhile, the NHS ester group reacts with primary amines in biomolecules, enabling efficient conjugation with a high degree of selectivity and minimal side reactions.

The unique properties of Azide-PEG-NHS make it an ideal candidate for drug delivery applications. By conjugating drugs with Azide-PEG-NHS, it is possible to create stable drug conjugates that can be targeted to specific sites in the body, leading to increased efficacy and reduced side effects. Moreover, Azide-PEG-NHS has been shown to improve the solubility and bioavailability of poorly soluble drugs, making it an attractive option for drug development.