Amino-PEG-Amine (NH2-PEG-NH2) is a bifunctional polyethylene glycol (PEG) compound with primary amine groups on both ends. It facilitates bioconjugation, surface modification, and crosslinking by forming stable bonds with carboxylic acids and NHS esters. Its PEG backbone enhances solubility and biocompatibility, making it ideal for applications in drug delivery, protein labeling, and nanoparticle formulation.
Amino-PEG-Amine
Amino-PEG-Amine (NH2-PEG-NH2), also known as amine-PEG-amine, is a bifunctional polyethylene glycol (PEG) derivative. It features two reactive primary amine groups at both ends, which can rapidly form stable amide bonds with carboxylic acids or NHS esters. This makes it highly valuable for various applications, such as bioconjugation, surface modification, and crosslinking in chemical and biological research.
Key Features:
- Biocompatibility: The PEG spacer enhances solubility and reduces immunogenicity, making it useful in biological environments.
- Versatile Linker: It reacts efficiently with activated carboxyl groups, facilitating use in drug delivery, protein labeling, and surface functionalization.
- Adjustable Molecular Weight: Available in various molecular weights, ranging from 1kDa to over 20kDa, allowing for precise tuning based on application needs.
It is commonly applied in the development of antibody-drug conjugates (ADCs), nanoparticle formulations, and protein modifications where the PEG component provides stability and the amine groups enable functionalization.