Aldehyde Linkers are bioorthogonal linkers for hydrazide and oxyamines. They readily react with hydrazides and oxyamines to form stable linkage under neutral conditions. The carbon-nitrogen double bonds hydrolyze under mild acidic conditions. Therefore they are also classified as cleavable linkers.
Aldehyde linkers have been successfully used to generate a variety of pH-sensitive conjugates of the anticancer drugs. They are also widely used in drug delivery application and glycoprotein and polysaccharide research.
AxisPharm provide a broad range of aldehyde linkers with various functional groups, such as azide, alkyne, and acid, etc. to support the bioconjugation research.