Ald-PEG-acid（Acid-PEG-Ald） is a versatile chemical compound that has gained significant attention in pharmaceutical research and development due to its unique properties and potential applications. It is a member of the polyethylene glycol (PEG) family, which is widely used in various industries due to its ability to improve solubility, stability, and bioavailability of drugs.
Ald-PEG-acid is a bifunctional PEG derivative that contains an aldehyde group and a carboxylic acid group. This unique combination of functional groups allows Ald-PEG-acid to be used as a crosslinking agent for biomolecules and a building block for drug conjugation.
Ald-PEG-acid has been extensively used in the development of novel drug delivery systems, such as PEGylation and antibody-drug conjugates (ADCs). PEGylation involves attaching PEG chains to drugs or proteins, which improves their pharmacokinetic properties by increasing their circulation time and reducing their immunogenicity. ADCs are a promising class of anticancer agents that consist of a cytotoxic drug conjugated to a monoclonal antibody via a PEG linker.