PLGA SH Capped, MW 10K is a high-molecular-weight, thiol-terminated reactive biodegradable PLGA copolymer engineered for durable thiol-specific bioconjugation, long-cycle nanoparticle functionalization, and prolonged sustained targeted drug delivery research. Featuring enhanced structural rigidity, excellent morphological stability and extended hydrolytic degradation kinetics, this polymer retains highly active terminal thiol functional groups. It serves as a high-performance reactive building block for long-term sulfhydryl click chemistry, durable biomolecule immobilization, and advanced long-cycle biomedical material functional modification.
Basic Specifications
Alternative Name: PLGA-SH, Thiol-terminated PLGA
Polymer Composition: Poly(lactic-co-glycolic acid)-Thiol
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 65:35, 75:25, 85:15, Custom synthesis
Functional Groups: Thiol (SH)
Appearance: White to off-white solid
Key Features and Benefits
Highly Active Terminal Thiol (SH) Reactivity: Modified with high-purity terminal thiol groups, enabling efficient, high-specificity covalent conjugation with maleimide, vinyl sulfone, gold nanoparticles and disulfide bonds under mild physiological conditions. It delivers high-yield, low-side-reaction bioconjugation with persistent reactivity, supporting durable and reliable modification of antibodies, functional peptides, therapeutic proteins and targeted ligands for long-cycle biomedical research.
Tunable Lactide-Glycolide Ratio System: Covers mainstream industrial ratios including 65:35, 75:25, 85:15 and supports full custom synthesis. Accurate ratio tuning flexibly adjusts polymer hydrophilicity, long-term degradation kinetics and structural properties, perfectly adapting to long-cycle sustained-release formulations and high-stability biomaterial modification scenarios.
Enhanced 10K High Molecular Weight Performance: The 10K high molecular weight forms dense polymer chain entanglement, delivering significantly improved structural rigidity, anti-deformation capability and morphological durability compared with medium and low-MW PLGA. It features uniform, prolonged hydrolytic degradation behavior, effectively preventing nanoparticle structural fatigue, collapse and premature drug leakage, perfectly suitable for fabricating high-stability nanoparticles and microspheres for long-term sustained delivery systems.
Excellent Biocompatibility & Prolonged Uniform Degradation: Possesses premium physiological biocompatibility and biosafety. The PLGA backbone undergoes mild, steady and homogeneous hydrolysis into non-toxic endogenous lactic acid and glycolic acid throughout long degradation cycles without inflammatory stimulation or residual toxicity. Terminal thiol groups exhibit low biological irritation, fully complying with strict safety standards for in vitro conjugation experiments and long-term in vivo biomedical applications.
Long-Term Stable & Repeatable Conjugation Performance: Precise terminal SH capping technology ensures uniform reactive group distribution and consistent long-term batch-to-batch reactivity. The formed covalent linkage features exceptional chemical stability, effectively preventing biomolecule shedding and functional attenuation during prolonged polymer degradation, guaranteeing stable, reproducible results for long-cycle experiments and sustained-release formulations.
Applications
Durable Thiol-Specific Bioconjugation: Widely utilized for high-stability covalent coupling and immobilization of maleimide-modified biomolecules, gold nanoparticles, functional peptides and therapeutic proteins, supporting durable construction of long-acting targeted delivery platforms and high-performance biomedical probes.
Long-Cycle Sustained Targeted Drug Delivery: Optimized for fabricating high-stability PLGA nanoparticles and microspheres, achieving uniform long-term sustained drug release and stable active targeted delivery, suitable for chronic disease treatment and long-acting sustained-release formulation development.
High-Stability Nanoparticle Surface Functionalization: Acts as a premium thiol-reactive precursor for advanced biodegradable carrier surface engineering, providing abundant active SH sites for post-synthesis ligand grafting, significantly improving carrier structural durability, in vivo circulation stability and targeted accumulation efficiency.
Long-Term Advanced Biomedical Material Modification: Applicable for functional crosslinking and surface modification of long-cycle degradable hydrogels and tissue engineering scaffolds, supporting the construction of durable responsive biodegradable materials and stable functional biomedical interfaces for advanced long-term biomedical research.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, oxygen-free and moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to prevent thiol oxidation and disulfide crosslinking, preserving polymer reactive activity and structural integrity.
Handling: Avoid oxygen exposure, moisture intrusion, high-temperature environments and prolonged air contact to prevent thiol group oxidation and deactivation. Avoid repeated freeze-thaw cycles to maintain stable conjugation efficiency.
PLGA SH Capped, MW 10K integrates durable terminal thiol reactivity, enhanced structural rigidity, tunable degradation performance and prolonged hydrolytic kinetics, serving as a high-performance thiol-reactive biodegradable polymer for long-term bioconjugation, long-cycle sustained targeted drug delivery and durable advanced biomedical material functional modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.