PLGA SH Capped, MW 40K is a thiol-capped poly(lactic-co-glycolic acid) with a molecular weight of approximately 40K. It combines a biodegradable PLGA backbone with terminal thiol functionality specifically for thiol-selective conjugation, polymer functionalization, nanoparticle modification, surface modification, drug-delivery research, and biomaterial development.
Key Features and Benefits
- Thiol-Capped PLGA: Combines biodegradable poly(lactic-co-glycolic acid) with terminal thiol functionality for chemical modification and conjugation.
- MW 40K: Provides a relatively high molecular weight for polymer matrix formation, particle formulation, and biodegradable material research.
- Thiol Functionality: The terminal –SH group provides a reactive site specifically for thiol-selective coupling, polymer modification, and surface attachment.
- Biodegradable Copolymer: The PLGA backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Lactide-Glycolide Backbone: Combines lactic acid- and glycolic acid-derived units in a biodegradable polyester platform widely used in polymer and drug-delivery research.
- Thiol-Reactive Conjugation: Supports coupling with maleimide, vinyl sulfone, and other compatible thiol-reactive functional groups.
- Versatile Functionalization Platform: Terminal thiol functionality specifically enables attachment of compatible polymers, ligands, probes, surfaces, and other functional components.
Applications
- Thiol-Maleimide Coupling: Supports selective conjugation with maleimide-functionalized molecules, polymers, and materials.
- Polymer Functionalization: Enables preparation of functional PLGA derivatives and more complex polymer architectures.
- Bioconjugation: Supports attachment of compatible biomolecules, ligands, peptides, and other functional components through thiol-reactive chemistry.
- Nanoparticle Functionalization: Supports preparation and surface modification of biodegradable PLGA nanoparticles and related delivery systems.
- Surface Modification: Enables thiol-mediated attachment and functionalization of compatible surfaces and materials.
- Gold Surface Functionalization: Thiol functionality supports interaction with gold surfaces for nanoparticle, coating, and surface-modification research.
- Drug Delivery: Supports development of biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and prolonged air exposure.
- Handling: Minimize exposure to oxygen and moisture to reduce thiol oxidation and disulfide formation. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
PLGA SH Capped, MW 40K provides a biodegradable PLGA platform with terminal thiol functionality for thiol-selective conjugation and material functionalization and specifically supports polymer modification, bioconjugation, nanoparticle functionalization, surface modification, drug-delivery research, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.