This 15K maleimide‑functionalized PCL sits as a premium mid‑to‑ultra high molecular weight grade, bridging the stable circulation performance of 10K and the implant‑level robustness of 20K PCL‑Maleimide. Featuring extended polymer chains and significantly increased crystallinity compared to lower MW analogs, this material achieves balanced mechanical rigidity and moderate‑ultra slow hydrolytic degradation. Retaining fully active terminal maleimide reactive groups, it enables precise, thiol‑specific bioconjugation with peptides, proteins and targeting ligands. Tailored for long‑term in vivo experiments and durable structural constructs, 15K PCL‑Maleimide delivers steady long‑term stability without the overly rigid, ultra‑slow erosion characteristics of 20K polymers, making it ideal for prolonged drug delivery and semi‑implantable platform fabrication.
Key Features:
- Premium mid‑high‑weight PCL architecture with intensified chain entanglement, providing superior structural stability over 2K/3K/5K/10K maleimide PCL grades
- Moderate‑ultra slow degradation profile, supporting 6–12 week sustained structural integrity for long‑term biological and preclinical studies
- Consistently high maleimide end‑group activity, enabling reproducible thiol Michael‑addition conjugation in organic and mixed solvent systems
- Balanced hydrophobicity and solubility, allowing stable nanoparticle formation while supporting durable surface functionalization for scaffold materials
- Low residual impurities and well‑defined end‑group functionality, compliant with advanced cell experiments and prolonged in vivo evaluation
Applications:
- Fabrication of long‑stable targeted nanoparticles and micelles for sustained drug release and prolonged biodistribution studies
- Surface functionalization of semi‑implantable electrospun membranes and tissue engineering scaffolds for medium‑to‑long term tissue integration research
- Preparation of stable polymer‑protein and polymer‑ligand conjugates for persistent in vivo targeting systems
- Formulation development bridging long‑circulating nanocarriers and slow‑degrading implantable polymer platforms
- Advanced preclinical prototype testing requiring both bioconjugation flexibility and extended structural durability
Handling & Storage: Store the dried polymer powder at −20 °C under dry, inert gas protection and avoid prolonged light exposure. Maleimide functional groups are moisture‑sensitive and prone to hydrolytic inactivation. Equilibrate sealed vials completely to room temperature in a desiccator before opening to prevent condensation contamination. Prepare fresh polymer solutions using anhydrous organic solvents immediately before use; avoid long‑term storage of dissolved stocks. Intended for laboratory research only, not for human clinical use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.