PLGA SH Capped, MW 5K is a medium-molecular-weight, thiol-terminated reactive biodegradable PLGA copolymer engineered for stable thiol-specific bioconjugation, medium-cycle nanoparticle functionalization, and conventional sustained targeted drug delivery research. Balancing excellent organic solubility, moderate structural rigidity and steady uniform hydrolytic degradation, this polymer retains highly active terminal thiol functional groups. It serves as a versatile mainstream reactive building block for standardized sulfhydryl click chemistry, stable biomolecule immobilization, and routine biomedical material functional modification.
Basic Specifications
Alternative Name: PLGA-SH, Thiol-terminated PLGA
Polymer Composition: Poly(lactic-co-glycolic acid)-Thiol
Molecular Weight: Custom molecular weights available
Lactide:Glycolide Ratio: 65:35, 75:25, 85:15, Custom synthesis
Functional Groups: Thiol (SH)
Appearance: White to off-white solid
Key Features and Benefits
Highly Active Terminal Thiol (SH) Reactivity: Modified with high-purity terminal thiol groups, enabling efficient, high-specificity covalent conjugation with maleimide, vinyl sulfone, gold nanoparticles and disulfide bonds under mild physiological conditions. It delivers high-yield, low-side-reaction bioconjugation, supporting stable and repeatable modification of antibodies, functional peptides, therapeutic proteins and targeted ligands for medium-cycle biomedical research.
Tunable Lactide-Glycolide Ratio System: Covers mainstream industrial ratios including 65:35, 75:25, 85:15 and supports full custom synthesis. Accurate ratio tuning flexibly adjusts polymer hydrophilicity, degradation kinetics and solution properties, perfectly adapting to conventional medium-cycle sustained-release formulations and routine biomaterial modification scenarios.
Balanced 5K Medium Molecular Weight Performance: The standard 5K medium molecular weight achieves an optimal balance of solubility and structural stability. Compared with low-MW PLGA, it features denser chain entanglement, enhanced morphological rigidity and uniform moderate degradation speed. It effectively avoids burst release and structural instability, making it ideal for preparing structurally stable nanoparticles and microspheres for medium-term sustained delivery systems.
Excellent Biocompatibility & Uniform Moderate Degradation: Possesses reliable physiological biocompatibility and biosafety. The PLGA backbone undergoes steady, homogeneous hydrolysis into non-toxic endogenous lactic acid and glycolic acid without inflammatory stimulation or residual toxicity. Terminal thiol groups exhibit low biological irritation, fully complying with safety standards for in vitro conjugation experiments and medium-term in vivo biomedical applications.
Stable & Repeatable Conjugation Performance: Precise terminal SH capping technology ensures uniform reactive group distribution and consistent batch-to-batch reactivity. The formed covalent linkage features reliable chemical stability, effectively preventing biomolecule shedding and functional attenuation during medium-term polymer degradation, guaranteeing stable and reproducible experimental and formulation results.
Applications
Stable Thiol-Specific Bioconjugation: Widely utilized for standardized covalent coupling and immobilization of maleimide-modified biomolecules, gold nanoparticles, functional peptides and therapeutic proteins, supporting stable construction of targeted delivery platforms and biomedical probes for routine research.
Medium-Cycle Sustained Targeted Drug Delivery: Optimized for fabricating structurally stable PLGA nanoparticles and microspheres, achieving uniform medium-term sustained drug release and active targeted delivery, suitable for conventional disease treatment and routine sustained-release formulation development.
Stable Nanoparticle Surface Functionalization: Acts as a reliable thiol-reactive precursor for biodegradable carrier surface engineering, providing abundant active SH sites for post-synthesis ligand grafting, improving carrier targeting specificity, cellular uptake efficiency and structural stability.
Medium-Term Biomedical Material Modification: Applicable for functional crosslinking and surface modification of medium-cycle degradable hydrogels and tissue engineering scaffolds, supporting the construction of stable responsive biodegradable materials and functional biomedical interfaces for routine research.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, oxygen-free and moisture-proof container. Inert gas sealing is strongly recommended for long-term storage to prevent thiol oxidation and disulfide crosslinking, preserving polymer reactive activity and structural integrity.
Handling: Avoid oxygen exposure, moisture intrusion, high-temperature environments and prolonged air contact to prevent thiol group oxidation and deactivation. Avoid repeated freeze-thaw cycles to maintain stable conjugation efficiency.
PLGA SH Capped, MW 5K integrates stable terminal thiol reactivity, balanced structural rigidity, tunable degradation performance and moderate hydrolytic kinetics, serving as a versatile standard thiol-reactive biodegradable polymer for routine bioconjugation, medium-cycle sustained targeted drug delivery and stable biomedical material functional modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.