PLGA NHS Capped, MW 40K (PLGA‑NHS) is a premium ultra-high‑molecular‑weight, amine‑reactive biodegradable PLGA copolymer, representing the highest stability grade in the PLGA-NHS series. Functionalized with terminal N‑hydroxysuccinimide (NHS) ester groups, this polymer features ultra-compact chain entanglement, maximum mechanical toughness, and multi-year ultra-slow hydrolytic degradation kinetics. It maintains stable amine-specific conjugation activity throughout extreme long-term in vivo cycles, serving as a top-tier implantable-grade reactive building block for multi-year sustained drug delivery, ultra-durable biomaterial functionalization and high-standard translational biomedical research.
Basic Specifications
Alternative Name: PLGA‑NHS, PLGA N‑hydroxysuccinimide Capped
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑NHS
Molecular Weight: 40K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Highly Active Terminal NHS Ester Reactivity: Modified with high-purity terminal NHS ester groups, enabling highly specific, efficient covalent conjugation with primary amine (-NH₂) groups under mild physiological conditions. The reaction forms stable, irreversible amide bonds with zero non-specific interference and minimal side reactions. It retains consistent reactive activity throughout multi-year degradation cycles, supporting permanent and ultra-stable covalent modification of high-value antibodies, therapeutic proteins, long-acting peptides and amine-terminated functional ligands for clinical-grade long-cycle research.
Top-Tier 40K Ultra-High Molecular Weight Performance: As the highest molecular weight specification in the PLGA-NHS product line, 40K grade forms extremely dense and compact polymer chain entanglement, delivering maximum structural rigidity, anti-fatigue toughness and permanent morphological stability. It possesses the slowest and most uniform degradation profile among all PLGA-NHS variants, completely eliminating particle deformation, structural collapse and premature drug release, perfectly tailored for multi-year ultra-long-acting implantable delivery systems and high-rigidity durable carrier fabrication.
Clinical-Grade Biocompatibility & Multi-Year Mild Degradation: Built with high-purity biocompatible PLGA backbone, achieving gradual, mild and homogeneous hydrolysis into endogenous non-toxic lactic acid and glycolic acid over multi-year cycles. No local inflammation, tissue irritation, immune rejection or residual toxicity is generated during the entire degradation process, fully complying with clinical implant safety standards and high-level translational medical research requirements.
Permanent Multi-Year Conjugation Stability: Precision terminal single-point NHS capping technology ensures uniform reactive group distribution and long-term activity retention. The formed amide covalent bond exhibits extreme chemical inertness and anti-aging performance, resisting dissociation and functional attenuation during multi-year polymer erosion. It permanently maintains the biological activity of conjugated biomolecules, delivering ultra-stable and repeatable results for long-term implantable formulations.
Ultra-Durable Implantable Material Compatibility: The mild amine-specific reaction mechanism supports non-damaging post-synthesis functionalization of ultra-tough implantable nanoparticles and multi-year service-life tissue engineering scaffolds. It perfectly preserves biomolecular activity and carrier structural integrity, fully adapting to high-standard long-term implantable biomedical engineering and clinical transformation research.
Applications
Multi-Year Permanent Amine Bioconjugation: Ideal for permanent covalent immobilization and functional modification of high-value therapeutic antibodies, long-acting protein drugs, sustained-release polypeptides and targeted ligands, supporting multi-year stable biomolecular assembly and persistent in vivo biological tracing.
Multi-Year Ultra-Long Sustained Drug Delivery: Exclusively optimized for implantable ultra-long-acting drug delivery devices and multi-year controlled-release formulations, breaking the cycle limitation of conventional medium and high-MW PLGA materials, suitable for long-term chronic disease intervention and clinical long-acting pharmaceutical development.
Permanent Implantable Nanoparticle Functionalization: Serves as a top-grade reactive precursor for ultra-durable implantable carrier surface engineering, stably anchoring targeting groups to achieve multi-year in vivo structural stability, persistent circulation retention and long-term targeted enrichment effect.
Multi-Year Implantable Biomedical Material Research: Widely applied for functional modification of long-service-life degradable hydrogels and implantable tissue engineering scaffolds, supporting the development of high-toughness, multi-year durable intelligent biomedical materials and clinical implantable therapeutic devices.
Storage and Handling
Storage: Store at –20 °C in a fully sealed, dry, moisture‑proof container. Inert gas sealing is strongly recommended for long‑term storage to prevent NHS ester hydrolysis and preserve polymer reactive activity and structural integrity.
Handling: Strictly avoid moisture intrusion, high‑temperature environments and prolonged air exposure, as NHS groups are highly moisture‑sensitive and prone to deactivation. Avoid repeated freeze‑thaw cycles to maintain stable conjugation efficiency.
PLGA NHS Capped, MW 40K integrates permanent amine-specific NHS reactivity, top-tier structural rigidity and multi-year ultra-long degradability, acting as a premium clinical-grade reactive biodegradable polymer for multi-year permanent bioconjugation, ultra-long-acting implantable sustained drug delivery and ultra-durable biomedical material modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.