PLGA N3 Capped, MW 2K (PLGA‑Azide) is a low‑molecular‑weight, azide‑terminated click‑reactive biodegradable PLGA copolymer optimized for bioorthogonal bioconjugation, rapid‑degrading nanoparticle engineering, and short‑cycle targeted drug‑delivery research. It supports multiple standard and custom lactide‑glycolide ratios, delivers excellent organic solubility and fast hydrolytic degradation, and serves as a versatile building block for CuAAC‑ and copper‑free click‑chemistry biolabeling and nanoparticle surface modification.
Basic Specifications
Alternative Name: PLGA‑Azide, PLGA‑N3
Polymer Composition: Poly(D,L‑lactide‑co‑glycolic acid)‑Azide
Lactide Ratio: 50:50, 65:35, 75:25, 85:15, Custom synthesis
Molecular Weight: 2K, Custom
Appearance: White to off‑white solid
Key Features and Benefits
Terminal Azide (‑N₃) Click Reactivity: Terminal azide functional group enables highly selective bioorthogonal click conjugation. It reacts efficiently with alkyne, DBCO or BCN moieties via CuAAC or copper‑free strain‑promoted azide‑alkyne cycloaddition (SPAAC) under mild physiological conditions, forming stable triazole linkages with minimal side‑reactions, ideal for sensitive biomolecule modification.
Multi‑Ratio & Custom Synthesis Support: Covers mainstream 50:50, 65:35, 75:25, 85:15 lactide‑glycolide ratios plus full custom synthesis. Precise ratio adjustment flexibly tunes polymer hydrophilicity, degradation velocity and particle morphology to satisfy diverse fast‑release and bio‑orthogonal modification workflows.
Low 2K Molecular Weight Advantages: Low‑molecular‑weight backbone grants superior solubility in common organic solvents and fast, homogeneous hydrolytic degradation. It facilitates rapid carrier erosion and complete cargo release, well‑suited for short‑term drug‑delivery systems and quick surface bio‑orthogonal functionalization.
Excellent Biocompatibility & Biodegradability: Possesses high biosafety and physiological compatibility, hydrolyzing fully into non‑toxic lactic acid and glycolic acid without inflammatory residues, compatible with in‑vitro click‑conjugation assays and short‑term in‑vivo biomedical applications.
Reliable Conjugation Consistency: Uniform terminal N3 capping ensures consistent reactive‑group loading and repeatable click‑reaction yields. The resulting triazole bond is chemically stable, resisting dissociation during polymer degradation and preserving the bio‑function of conjugated ligands and probes.
Applications
Bioorthogonal Click‑Chemistry Bioconjugation: Widely used for covalent coupling of alkyne‑/DBCO‑modified peptides, proteins, oligonucleotides, fluorophores and targeting ligands via CuAAC or copper‑free SPAAC click chemistry.
Rapid‑Release Targeted Drug Delivery: Suited for fabricating fast‑degrading PLGA nanoparticles and microspheres, enabling short‑cycle controlled release and bio‑orthogonally‑functionalized active‑targeted delivery systems for acute‑therapy research.
Nanoparticle Surface Bio‑Orthogonal Functionalization: Acts as a reactive polymer precursor for surface engineering of biodegradable carriers, introducing click‑handle sites for post‑fabrication ligand‑grafting without harming pre‑formed particle morphology.
Biodegradable Scaffold & Hydrogel Modification: Applied for bio‑orthogonal functionalization of degradable hydrogels and tissue‑engineering scaffolds to construct custom reactive biomedical interfaces and smart biomaterials.
Storage and Handling
Storage: Store at –20 °C in sealed, dry, moisture‑proof container. Inert‑gas sealing is recommended for long‑term preservation to retain azide reactivity and polymer integrity.
Handling: Avoid moisture, high‑temperature exposure and prolonged air contact; avoid repeated freeze‑thaw cycles. Avoid strong impact or heating of neat solid azide‑functionalized polymer. Handle in accordance with azide‑containing material safety guidelines.
PLGA N3 Capped, MW 2K combines bioorthogonal azide click‑reactivity, favorable solubility and fast degradability with tunable lactide‑glycolide ratios, functioning as a universal click‑reactive biodegradable polymer for bio‑orthogonal bioconjugation, rapid‑release targeted drug delivery and degradable biomaterial modification research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.