DBCO-C5 acid
This product is a dibenzocyclooctyne (DBCO) derivative with a five-carbon linker terminating in a carboxylic acid. The strained DBCO group enables rapid copper-free click chemistry with azides, while the carboxyl group allows further functionalization via amide coupling. The C5 spacer provides flexibility and accessibility, making this reagent especially ideal for bioconjugation and probe development.
Key Features and Benefits
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DBCO Group: Supports fast, copper-free strain-promoted azide–alkyne cycloaddition (SPAAC) with azides.
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C5 Linker: Provides spacing and flexibility between functional groups.
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Carboxylic Acid Terminus: Enables coupling with amines through amide bond formation.
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Bioorthogonal Reactivity: Suitable for labeling under physiological conditions without metal catalysts.
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High Purity: Produced to ≥95% purity for reliable research applications.
Applications
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Bioconjugation: Couples biomolecules, peptides, or polymers through SPAAC or amide bond chemistry.
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Probe Development: Builds DBCO-functionalized probes for imaging and diagnostic studies.
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Drug Delivery: Serves as a linker for targeted therapeutics and PEGylated systems.
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Chemical Biology: Facilitates copper-free labeling in living systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed container, protected from moisture and light.
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Handling: Dissolve freshly before use; avoid repeated freeze–thaw cycles.
This product integrates copper-free click chemistry with a reactive carboxyl group, specifically offering a versatile linker for conjugation, probe development, and targeted delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
