UV Cleavable Biotin-PEG2-Azide
This product is a heterobifunctional linker featuring a biotin moiety for high-affinity avidin/streptavidin binding, an azide for click chemistry, and a UV-cleavable spacer. The PEG2 chain provides hydrophilicity and flexibility, making it especially useful for reversible bioconjugation, probe design, and advanced drug delivery applications.
Key Features and Benefits:
-
Biotin Moiety: Ensures strong, specific binding to avidin/streptavidin.
-
Azide Group: Supports CuAAC or SPAAC click chemistry with alkynes.
-
UV-Cleavable Spacer: Enables reversible, light-triggered release.
-
PEG2 Spacer: Enhances solubility and steric accessibility.
-
High Purity: Guarantees reproducibility in sensitive applications.
Applications:
-
Reversible Bioconjugation: Allows controlled capture and UV-triggered release.
-
Probe Development: Builds cleavable biotinylated probes for imaging and diagnostics.
-
Drug Delivery: Enables photo-responsive release systems.
-
Synthetic Chemistry: Provides a modular linker for advanced conjugation strategies.
Storage and Handling:
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure.
This product combines biotin affinity, click chemistry reactivity, and UV-triggered release in a compact PEG2 scaffold, specifically offering precision for advanced bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
