THP-PEG2-bromide

THP-PEG2-bromide

This product is a heterobifunctional PEG linker containing a tetrahydropyranyl (THP) protecting group, a PEG2 spacer, and a terminal bromide. The bromide functions specifically as an excellent leaving group, enabling nucleophilic substitution with amines, thiols, or alkoxides. The THP group protects hydroxyl functionality for controlled deprotection, while the PEG2 spacer enhances solubility and flexibility. This compact design makes it an especially useful intermediate for bioconjugation and synthesis.

Key Features and Benefits

• Bromide Group: Supports nucleophilic substitution with diverse nucleophiles.

• THP Group: Provides orthogonal hydroxyl protection for selective chemistry.

• PEG2 Spacer: Improves solubility and reduces steric hindrance.

• Compact Scaffold: Balances reactivity and solubility in a short linker.

• High Purity: Produced to ≥95% purity for consistent performance.

Applications

• Bioconjugation: Builds intermediates for multifunctional conjugates.

• Probe Development: Introduces protected hydroxyl and reactive halide groups.

• Drug Delivery: Functions as a modular linker in therapeutic designs.

• Polymer and Material Science: Installs functional PEG units into polymers.

Storage and Handling

• Storage: Store at –20 °C in a sealed, desiccated container.

• Handling: Use freshly prepared solutions; bromides are moisture-sensitive.

This product integrates halogen reactivity with hydroxyl protection in a PEG2 scaffold, providing an especially versatile tool for controlled conjugation and synthetic applications.

AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.